Abstract: Objective Combing literature about medicinal property, effect, toxicity ofB , to provide Bupleurum chinense,to provide literature accordance and idea for the relevance research of "medicinal property-effect-toxicity". Methods Ancient books, literature in past dynasties about Bupleurum chinense were collated, analyzed and summarized. Results There are different records on the efficacy, indications of Bupleurum chinense in ancient literature were not classified as toxical chemicals in the ancient literature, but in the process of clinical application, some physicians come to realize the toxicity and side effects of Bupleurum chinense. Conclusion Literature study shows that there are certain toxicity and side effects of Bupleurum chinense , consistency with the records about Bupleurum chinense "robbing hepatic yin" and modern clinical adverse reactions. Some physicians believe that is the first drug to treat "liver qi stagnation". At present the researches of the medicinal, effect, material basis and toxicity in are isolated, so how to balance the relationship between "shuganjieyu" and" Bupleurum chinenserobbing hepatic yin", to observe and find the toxicity starting from the effect of Bupleurum chinense, and using modern language to clarify the intrinsic nature relationship between effect and toxicity of becomea problem that should be solved urgently to be more effective and safe application of Bupleurum chinense .

Key words: Bupleurum chinense, ancient literature, "medicinal property-efficacy-toxicity", relevance