Abstract: Current situation of hypophosphatemic osteomalacia after adefovir dipivoxil therapy for hepatitis B with low dosage home and abroad was retrospectively analyzed. Investigations revealed hypophosphatemic osteomalacia might occur in chronic hepatitis B patients with long -term use of adefovir dipivoxil at dosage of 10mg per day. The clinical features were slowly progressive distal muscle weakness, bone pain or even fracture. For it's difficulty to accurately diagnose in clinic and there is no warnings in the domestic drug specifications, more attention should be paid to the adverse reaction. The frequency and influence factors should be further researched.

Key words: adfovir dipivoxil, hypophosphatemia, osteomalacia