Abstract: Objective To develop active surveillance and assessment system for the detection and prevention of ADE in hospitalized patients in order to make up for the deficiency of the voluntary reporting and improve the status of "passive surveillance" to "real-time monitoring". Methods The principles of triggers technology were applied to the development of the system. The accuracy of the system was evaluated by the Results of the verification of clinical pharmacists. Results Detection rules of drug-related thrombocytopenia, anemia, liver damage, kidney damage were designed. The key technical route of automatic monitoring, medication review, assistance evaluation, characteristics analysis, high-risk screening were established and the software was developed to dock with hospital voluntary reporting system. +PV was 69.4%. Conclusion The computerized survelliance and auxiliary evaluation of adverse drug events was developed, and the electronic platform with SRS of ADE linkage monitoring was established. The study providesa new way of thinking and practical technology tools in order to carry out the drug safety monitoring.

Key words: adverse drug reaction, active surveillance, intensive monitoring, computerized detection and assessment, clinical pharmacists