Analysis on Composition Principles of Traditional Chinese Medicine Prescriptions for Prostate Cancer

Abstract

Abstract: Objective To analyze the composing principles of herbs in the prescriptions for prostate cancer by using Traditional Chinese Medicine Inheritance System, and make predictions of new formulations according to the composing principles. Methods By retrieving Chinese medicine prescriptions about treatments of prostate cancer in China National Knowledge Infrastructure(CNKI), VIP net-Warehouse online publishing platform and Wan-fang Data-Knowledge service platform, the papers on prescriptions for prostate cancer were collected, and then Traditional Chinese Medicine Inheritance System was used to set up a database so as to analyze the composing principles of herbs in the prescriptions and predict new prescriptions. Results The 289 prescriptions in the database were screened to achieve 40 commonly used Traditional Chinese medicines, 14 commonly used drug combination modes,6 core combinations of new prescriptions and 3 new prescriptions. Analysis showed that the effects of herbs are mainly Invigorating Qi and Reinforcing Liver and Kidney, partially Clearing Heat Anti-toxicant, Clearing Heat and Dissolving Dampness and Promoting Blood Circulation for Removing Blood Stasis. The effects of new prescriptions obtained by cluster analysis were speculated to be Benefiting Qi for Nourishing Yin, Activating Blood and Resolving Accumulation; Heat Anti-toxicant, Promoting Blood Circulation for Removing Blood Stasis and Reinforcing Liver and Kidney. Conclusion Composing principles of herbs in the prescriptions for prostate cancer that we studied based on Traditional Chinese Medicine Inheritance System provides a reference for clinical practice. The predicted new prescriptions are in line with the clinical treatment considerations and provide a preliminary basis for clinical treatment and drug development

Key words: prostate cancer, traditional Chinese medicine, Traditional Chinese Medicine Inheritance System, prescription principles

CLC Number:

R969.3

AN Wan-li, YANG Hong. Analysis on Composition Principles of Traditional Chinese Medicine Prescriptions for Prostate Cancer[J]. Chinese Journal of Pharmacovigilance, 2018, 15(3): 158-162.

References

[1] 陈孝平,汪建平.外科学[M].8版. 北京:人民卫生出版社,2013:587-588.
[2] EAU, European Association of Urology. EAU guidelines on prostate cancer[Z].Europe.EAU,2015:30-97.
[3] 司富春,杜超飞.近30年前列腺癌的中医证候及方药规律分析[C]//中华中医药学会中医方证基础研究与临床应用学术交流会. 2013:226-233.
[4] 唐仕欢,申丹,卢朋,等.中医传承辅助平台应用评述[J].中华中医药杂志,2015,30(2):329-331.
[5] 宋竖旗,李灿.张亚强.治疗晚期前列腺癌经验[J].中国中医药信息杂志,2010,17(1):85-86.
[6] 崔芳囡.前列腺癌的中医病因病机与治疗-贾立群经验总结[J].辽宁中医杂志,2011,38(11):2142-2144.
[7] 王金秀,李小江,陈军.贾英杰论前列腺癌的中医病机与治疗[J].新中医,2014,46(4):20-23.
[8] 宋竖旗,卢建新,张亚强.中医药治疗前列腺癌的新进展与思考[J].中国中西医结合外科杂志, 2015,21(6):629-632.
[9] 吕立国. 扶正抑瘤法对前列腺癌D2期骨转移患者生存质量及PSA、骨转移灶的影响[D]. 广州中医药大学, 2007.
[10] 宋竖旗, 卢建新. 调理脾胃法治疗晚期前列腺癌[J]. 中国中医药信息杂志, 2013,20(10):90-91.
[11] 王金秀,李小江,陈军,等. 贾英杰论前列腺癌的中医病机与治疗[J]. 新中医, 2014,46(4):20-23.
[12] 李承功. 周智恒治疗前列腺疾病经验[J]. 江西中医药, 2002,33(2):5-5.
[13] 陈智锋,余绍龙,林峰.内分泌治疗联合中医养阴益肾对晚期前列腺癌患者的PSA及生活质量的影响[J]. 吉林医学,2013,34(22):4450-4451.
[14] 黄桂军,王华,陈朝宽,等. 扶正抑瘤汤对晚期前列腺癌患者生存期和生活质量的影响[J]. 江苏中医药,2010,42(6):18-20.
[15] 庞雪莹,刘松江.自拟前列癌方对晚期前列腺癌患者的PSA指标及生存质量的干预[J].中医药信息, 2012, 29(4):50-52.
[16] 钟 ,赖海标,黄智峰,等. 中药川龙抑癌汤配合间断的抗雄激素治疗晚期前列腺癌[C]// 第七次中国中西医结合泌尿外科学术年会暨第二次广东省中西医结合泌尿外科学术年会.2009.
[17] 吴燕敏,马国花,魏睦新. 知柏地黄汤加味治疗早期前列腺癌38例[J]. 时珍国医国药,2009,20(4):951-952.
[18] 余绍龙,陈智锋,林峰,等. 六味地黄汤联合内分泌治疗晚期前列腺癌的临床观察[J]. 中国当代医药,2010,17(24):93-93.
[19] 苏淼毅. 知柏地黄丸治疗前列腺癌内分泌治疗所致副作用的临床观察[D]. 福建中医药大学,2013.
[20] 马国花,吴燕敏,魏睦新.魏睦新采用中医待机疗法治疗早期前列腺癌经验[J]. 中国中医药信息杂志, 2008,15(9):88-89.
[21] 卢伟. 王居祥主任医师治疗前列腺癌经验举隅[J]. 南京中医药大学学报, 2005, 21(3):186-187.
[22] 周红, 何秀云, 邹清芳. 六味地黄汤加味联合比卡鲁胺治疗晚期前列腺癌疗效观察[J]. 四川中医, 2013,31(6):95-96.