Experimental Study on Acute Toxicity of the Aconiti kusnezoffii Radix and Its Processed Products

Abstract

Abstract: Objective To discuss the principle of the processing method of raw Aconiti kusnezoffii Radix by comparing the acute toxicity of seven kinds of samples made with Aconiti kusnezoffii Radix or its processed products. Methods The median lethal dose (LD50) or the maximum dose of seven kinds of samples were measured by gavage method on mice. Results The LD50 of powder of raw Aconiti kusnezoffii Radix, powder of Aconiti kusnezoffii Radix processed with Chebulae Fructus, decoction of compatibility of Aconiti kusnezoffii Radix and Chebulae Fructus, decoction of Aconiti kusnezoffii Radix processed with Chebulae Fructus, decoction of raw Aconiti kusnezoffii Radix decoction was respectively 0.7009, 1.1690, 2.5600, 4.0000, 15.3 200 g·kg-1. The MTD of powder and decoction of Aconiti kusnezoffii Radix processed by pharmacopoeia method was respectively 20 g·kg-1 and 64 g·kg-1. Conclusion Powder of raw Aconiti kusnezoffii Radix had obvious toxicity, the acute toxicity of raw Aconiti kusnezoffii Radix was reduced to varying degrees. Powder and decoction of Aconiti kusnezoffii Radix processed by pharmacopoeia method had no obvious toxicity.

Key words: Aconiti kusnezoffii Radix, processed, processed with Chebulae Fructus, acute toxicity, LD50

CLC Number:

R965

LIU Shuai, LIU Xiao-yan, LI Yan, YANG Chang, LIU Qiu-yu, LI Fei, DU Hong. Experimental Study on Acute Toxicity of the Aconiti kusnezoffii Radix and Its Processed Products[J]. Chinese Journal of Pharmacovigilance, 2015, 12(9): 513-516.

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