Abstract: Objective The reputation theory in production of pharmaceutical manufacturers was used to identify the key factors that affect manufacturers integrity, in order to provide references to promote the integrity of our specification of phar-maceutical manufacturers. MethodsThe opportunistic behavior of pharmaceutical manufacturers was analyzed theoretically based on KMWR model of reputation theory, and identified the key factors that manufacturers implement the opportunistic behavior. Resultsand ConclusionUnder the conditions of incomplete information,pharmaceutical manufacturers have a tendency to take opportunistic behavior, and the signal display effect of reputation can inhibit the opportunistic behavior, and encourage manufacturers to maintain a good reputation, thereby improving product quality.

Key words: drug quality safety, KMRW model, opportunistic behavior