Abstract: ObjectiveTo observe the cough relieving, sputum elimination and anti-inflammation effects of Jinhuang Zhike Granule(JHZK). MethodsThe cough relief effect of JHZK was observed by ammonia water causing cough in mice and citric acid causing cough in guinea pigs. The sputum elimination effect of JHZK was studied by the observation of tracheal phenol red shedding in mice. The anti-inflammatory effect was tested by xylene swelling inducing on mice and rat's toe swelling test caused by carrageen. ResultsJHZK could significantly inhibit the incubation period and cough frequency of the model mice and guinea pigs induced by ammonia water and citric acid, and notably improve the tracheal phenol red excretion volume in mice, and inhibit acute inflammatory response in mice and rat respectively induced by xylene and carrageen. ConclusionJHZK has certain effects of cough relief, sputum elimination and anti-inflammatory effects.

Key words: Jinhuang Zhike Granule, relieving cough, reducing sputum, anti-inflammation