Abstract: Objective To analyze the monitoring Results of drug concentration in serum of vancomycin in Beijing Hospital and promote the individual administration of vancomycin. Methods The valid data of vancomycin in the hospital from 2010 to 2012 were retrieved, and a retrospective analysis was made on the distribution of blood concentration.Results There were 652 cases of 314 patients who were monitored vancomycin serum concentrations from 2010 to 2012. In the 652 cases of vancomycin surveyed, there were 154(23.62%) cases were monitored 2 hours peak concentration.Among them there were 81(52.60%) cases lower 25μ g·mL^-1 and 54(35.06%) cases of 25～40 μg·mL^-1 and 19(12.34%) cases over 40 μg·mL^-1. In the 652 cases of vancomycin surveyed, there were 498(76.38%) cases were monitored trough concentration. According to the standard of Geraci (therapeutic window of vancomycin: 5～10μ g·mL^-1), there were 66(13.25%) cases lower 5 g·mL^-1 and 153(30.72%) cases of 5～10μ g·mL^-1 and 279(56.02%)cases over 10μ g·mL^-1.According to the standard of vancomycin therapeutic guidelines(therapeutic window of vancomycin:15～20μ g·mL^-1), there were 366(73.49%) cases lower 15μ g·mL^-1 and 64(12.85%) cases of 15～20 μg·mL^-1 and 68(13.65%) cases over 20ug·mL^-1. Conclusion The intensity of vancomycin serum concentration monitoring was insufficient in Beijing Hospital. We should take action to strengthen publicity and encourage clinicians to raise awareness of detection.Secondly, another goal is to improve communications between clinicians and pharmacists. The vancomycin serum concentration monitoring should be closely combined with clinical practice and a further study should be conducted to investigate the therapeutic window of vancomycin for the Chinese population.

Key words: vancomycin, blood concentration monitoring, effective concentration range, individualized medication