A Systematic Review of Efficacy of Trimetazidine for Stable Angina Pectoris in Chinese People

Abstract

Abstract: Objective To evaluate the efficacy of trimetazidine(TMZ) in the treatment of stable angina pectoris(SAP). Methods All literatures related to trimetazidine were retrieved in the following databases as PubMed, EMbase, Cochrane Central Database, CBM, CNKI, VIP and WanFang Data. The literatures which met the inclusion and exclusion criteria were selected, data were extracted, the quality was evaluated, and then statistical Methods such as Meta-analysis were performed. Results A total of 13 RCTs involving 869 patients were included. The Meta -analysis showed that, compared with the control group, TMZ was significantly superior in the following5 aspects: total efficiency, weekly mean number of angina attacks, weekly nitroglycerin consumption, the time to 1 mm drop of ST segment and angina pectoris threshold. But TMZ has no significant difference in duration of doing exercise compared with the control group. Conclusion Based on current studies, TMZ is superior to other medicines in the control group for SAP at present. However, due to defect of the data analysis method, this Conclusion needs to be confirmed by more high quality, large sample, multi-center, double blind RCTs.

Key words: Chinese people, trimetazidine, stable angina pectoris, efficacy, Meta-analysis

CLC Number:

R453

ZHANG Jin -li ,YANG Xue ,ZHANG Hui -xia, LU Jie, WANG Li ,CHENG Gang . A Systematic Review of Efficacy of Trimetazidine for Stable Angina Pectoris in Chinese People [J]. Chinese Journal of Pharmacovigilance, 2013, 10(12): 723-729.

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