Abstract: Objective To study the clinical traits of granulocytopenia induced by vancomycin. MethodsClinical information of 38 granulocytopenia cases at our hospital from jaunary to june in 2006 was collected, and age, gender, medication, clinical manifestation of granulocytopenia and prognosis were analyzed. Results26 patients (68.42%) were male in 38 cases and 12 were female(31.58%). The average age was 39.66±9.86 years old. The course of treatment by vancomycin was 7~27 days. The minimum of leucocytes count was 0.49×109/L. Vancomycin withdrawal was adopted in all patients, among whom 6 patients received drugs to elevate leucocytes and 32 patients not received any special treatments. All patients' leucocytes and neutrophils returned to normal ranges after 2~7 days. ConclusionGranulocytopenia induced by vancomycin is reversible, whereas the risk of concurrent infection is increased, which should be paid much attention to.

Key words: Vancomycin, adverse reaction, granulocytopenia