Abstract: ObjectiveTo study the causative agents clinical types, therapy and prognosis of drug eruption. Methods166 cases of drug eruption admitted to our inpatients department since July 2008 to July 2010 were retrospectively analysed. The clinical records were studied. ResultsTotally 108 cases had definite allergic drugs and the major species were β-lactams(43 cases), traditional Chinese Medicine injections(15 cases), non-steroid anti-inflammatory drugs(7 cases) and antipodagrics(7cases). The most common clinical types were urticaria-like type(43 cases), measles type(28 cases) and erythema polymorphe(19 cases). Among 30 severe cases, the predominant allergic species were carbamazepine(5 cases) and allopurinol(7 cases). There were 113 cases with hematological abnormality, 18 cases with liver or kidney dysfunction. While among the 30 severe patients, there were 26 cases with hematological abnormality and 12 cases with liver or kidney dysfunction. ConclusionDrug ertuption is most frequently induced by antibacterial agents while severe type is usually caused by antipodagric or antiepileptic drugs. The severe hospitalized patients usually were old people, easily be accompanied with hepatic or renal damage, whom should be paid more attention to.

Key words: eruption, severe eruption, clinical analysis