Abstract: Objective To offer experimental basement for the elucidation of dependablity between "toxicity-efficacy" by researching the adjoint toxical and side effects of anti-inflammatory effect of water and alcohol extract from Fructus Bruceae. Methods The model of ear swelling by croton oil and granuloma by agar were made and model mice were administrated with water and alcohol extract from Fructus Bruceae of high, middle and low dosage 3/7 days continually.The activities of serum ALT, AST and contents of Cr, BUN were detected while the ratio of liver and kidney to body was measured. Results Both ear swelling by croton oil and granuloma by agar can be inhibited by multiple intragastric administration of water and alcohol extract from Fructus Bruceae. The swelling depressive rate of water extract was higher than that of alcohol extract and showed a well "dose-effect" relationship. The activities of serum ALT, AST and ratio of liver to body showed little change, but both the contents of Cr and BUN and ratio of kidney to body increased significantly with doses and time. Conclusion Both water and alcohol extract from Fructus Bruceae at effective dosage could efficiently inhibit acute and chronic inflammation.At the same time some toxical and side effects can be caused to kidney, however, the occurrence mechanism of its toxical and side effects still need further study.

Key words: Fructus Bruceae, anti-inflammatory, adjoint toxical and side effects