The Evaluation of Airway Remodeling in Asthma Patients by HRCT

Abstract

Abstract: Objective To explore the condition of airway remodeling in asthma patients by HRCT. Methods Everyone performed HRCT for the evaluation of the severity of asthma and airway remodeling. Quantitative assessment was used to analyze the thickness of airway wall(T, T/D) and airway w all area(WA, WA%). Results Comparison of Group1 (mild persistent asthma) and Group2(moderate and severe persistent) asthma with 20 control subjects revealed signif-icantly higher values of WA [(12.53±4.19)mm² for Group1, (14.68±5.96)mm² for Group2 and(9.32±3.78)mm² for controls, P<0.05], respectively and WA% of Group1 and Group2 were higher than control subjects,but no significant differences between each other.[(70.51±7.04)%, (73.50±7.27)% and (64.80±5.45)%, P<0.05]. T and T/D of Group2 were higher than Group1 and control subjects(P<0.05), but had no statistically significant differences between Group1 and control subjects(P>0.05). Conclusion HRCT is one of the Methods to evaluate the airway remodeling of asthma patients.

Key words: airway remodeling, high-resolution computed tomography(HRCT)

CLC Number:

R282

ZHANG Xiao-yan, LIN Jiang-tao, LI Xiang-ning, LIU Cui-li, YANG Meng, YU Hong-xia. The Evaluation of Airway Remodeling in Asthma Patients by HRCT[J]. Chinese Journal of Pharmacovigilance, 2010, 7(5): 272-276.

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