Research progress in pharmacology and safe use of Boletus edulis

doi:10.19803/j.1672-8629.20240069

Abstract

Abstract: Objective To summarize the research progress related to rare wild fungus, Boletus edulis, evaluate its safety, and give tips on safe use. Methods The morphological characteristics, phylogenetics, bioactive ingredients, pharmacological activity, and heavy metal enrichment of B. edulis were discussed. Results The fruiting body was rich in protein, amino acids, carbohydrates, dietary fiber, and mineral elements. The active ingredients such as polysaccharides, phenolic compounds, flavonoids, and new multifunctional proteins were the material basis for its pharmacological effects including antioxidant, anti-inflammatory, anti-tumor, and liver-protecting properties. B. edulis had superior pharmacological activity and was a candidate drug with broad clinical applications. However, B.edulis was likely to enrich heavy metals (Cd, Hg, As and Pb) and had potential risks so that never using wild B.edulis from land contaminated areas and choosing appropriate processing methods could effectively reduce the risk of heavy metal intake. Conclusion B.edulis is of superior medicinal value, but there are also potential safety risks that are to be avoided.

Key words: Boletus edulis, bioactive ingredients, pharmacological activity, candidate drugs, heavy metal enrichment, safe use

CLC Number:

R931

GAO Haiyun, LI Yao, CHEN Yuxin, LI Hui, LIU Tianrui, YUAN Yuan. Research progress in pharmacology and safe use of Boletus edulis[J]. Chinese Journal of Pharmacovigilance, 2024, 21(5): 507-512.

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