Research progress on targeting CD47 in treatment of lymphoma

doi:10.19803/j.1672-8629.20230332

Abstract

Abstract: CD47 is one of the emerging immune checkpoints in the treatment of lymphoma in recent years. The most important role of CD47 is to interact with the macrophage receptor SIRP α under the regulation of various pathways, thereby inhibiting the immune attacks of macrophages and enabling tumor cells to achieve immune escape. There are various of CD47 blocking molecules at present, among which CD47 monoclonal antibody is the first to be applied in clinical practice. In order to reduce the prominent adverse reactions of the blood system, new drugs such as selective SIRP α antibody and double clonal antibody and combined therapy have been further developed. This article mainly reviews the clinical research progress on the regulatory mechanism, adverse reactions and related CD47 blockades in the treatment of lymphoma, so as to further improve clinical development through the innovation and combination of CD47 blockers

Key words: CD47, signal regulatory protein α (sirp α), macrophage, lymphoma, cancer immunotherapy

CLC Number:

HE Huizhen, GUO Yixian, SUN Wanling. Research progress on targeting CD47 in treatment of lymphoma[J]. Chinese Journal of Pharmacovigilance, 2023, 20(9): 1071-1077.

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