Adverse reactions induced by anlotinib hydrochloride

doi:10.19803/j.1672-8629.2022.07.17

Abstract

Abstract: Objective To summarize the characteristics of adverse reactions caused by anlotinib, and provide reference for clinically safe use of tumor targeted therapy drugs. Methods The clinical data on 36 patients who had developed adverse reactions after using anlotinib targeted therapy between October 1, 2018 and December 31, 2019 in the Department of Oncology of our hospital was analyzed in terms of gender, age, types of disease, previous adverse reactions, and system-organs involved. Clinical manifestations, time of occurrence, grades of severity, outcomes and correlations were analyzed. Results A total of 65 cases of adverse reactions occurred in 36 patients who had taken anlotinib, including 49 cases of mild adverse reactions and 16 cases of severe ones. The main adverse reactions were hypertension, proteinuria, hand-foot syndrome, fatigue, oral ulcers. Conclusion With the increasing use of anlotinib in clinic, both the efficacy and related adverse reactions deserve attention in order to make medication safer.

Key words: anlotinib, adverse drug reaction, malignant tumor

CLC Number:

R979.1

CAO Yajie, XU Han, ZHOU Ningning, ZHONG Chunsheng. Adverse reactions induced by anlotinib hydrochloride[J]. Chinese Journal of Pharmacovigilance, 2022, 19(7): 775-778.

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