Determination of cis(trans)-THSG in Polygoni Multiflori Radix from different areas and Polygoni Multiflori Radix Preparata using different processing methods by UPLC

doi:10.19803/j.1672-8629.20210925

Abstract

Abstract: Objective To provide data for quality control of Polygoni Multiflori Radix (PMR) and processing standards for Polygoni Multiflori Radix Preparata (PMRP) by observing the changes of cis(trans)-THSG (2, 3, 5, 4'- tetrahydroxystilbene-2-O-β-D-glucoside) of this plant grown in different areas and processed differently and to explore the mechanism by which processing can reduce its toxicity and increase efficacy. Methods An HPLC method was employed to determine the contents of cis(trans)-THSG. Results The content of cis(trans)-THSG in PMR and PMRP ranged from 27.23 to 358.19 μg·g -1 and from 10.30 to 52.00 mg·g -1 respectively. Conclusion This method is simple, accurate and reproducible, which can be used for

Key words: Polygoni Multiflori Radix, Polygoni Multiflori Radix Preparata, high performance liquid chromatography(HPLC), cis-THSG, trans-THSG

CLC Number:

R283
R994.11

WANG Xueting, YANG Jianbo, GAO Huiyu, SONG Yunfei, CHENG Xianlong, GU Donglin, WANG Ying, MA Shuang-cheng, WEI Feng. Determination of cis(trans)-THSG in Polygoni Multiflori Radix from different areas and Polygoni Multiflori Radix Preparata using different processing methods by UPLC[J]. Chinese Journal of Pharmacovigilance, 2023, 20(4): 383-387.

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