Compatible Stability of Six Effective Components including Sodium Danshensu in Xiangdan Injection Mixed with Three Infusions

doi:10.19803/j.1672-8629.2021.12.07

Abstract

Abstract: Objective To study the stability of six effective components in Xiangdan injection after being mixed with glucose injection, sodium chloride injection and glucose sodium chloride injection, respectively.Methods The contents of sodium danshensu, protocatechuic aldehyde, caffeic acid, lithospermic acid, salvianolic acid B and salvianolic acid A in Xiangdan injection were determined by HPLC after they were mixed with glucose injection, sodium chloride injection and glucose sodium chloride injection, respectively. Results After mixture with sodium chloride injection, the contents of lithospermic acid and salvianolic acid A decreased gradually while caffeic acid increased gradually. After mixture with glucose sodium chloride injection, the contents of salvianolic acid A decreased and caffeic acid content increased gradually. Only the content of salvianolic acid A decreased slightly after it was mixed with glucose injection.Conclusion It is recommended that Xiangdan injection be used in compatibility with glucose injection and be used as soon as possible.

Key words: Xiangdan injection, infusion, compatibility, caffeic acid, lithospermic acid, salvianolic acid A

CLC Number:

R972R961

ZAN Ke, ZHOU Ying, LI Wenting, TAN Chunmei, ZHU Qinglan, MA Shuangcheng, ZHENG Cheng. Compatible Stability of Six Effective Components including Sodium Danshensu in Xiangdan Injection Mixed with Three Infusions[J]. Chinese Journal of Pharmacovigilance, 2021, 18(12): 1134-1137.

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