Abstract: Objective To analyze one case of severe adverse reactions—liver damage caused by latamoxef sodium for injection in order to provide reference for rational use of latamoxef sodium. Methods A clinical pharmacist participated in the treatment of one patient with cholecystitis. The pharmacist screened the drugs used by this patient before and after hospitalization to find the cause of liver damage. The drugs that might have caused liver injury were evaluated by the relevance evaluation standard for adverse drug reactions (ADR). Finally, it was determined that the drug that caused abnormal liver function was latamoxef sodium for injection. According to the clinical symptoms and laboratory examination indexes of the patient, glutathione was added as a symptomatic therapy to protect the liver. Latamoxef sodium was replaced by efoperazone/sulbactam sodium as an anti-infection therapy, followed by efficacy evaluation of drugs and liver function index detection. Results Clinicians adopted the advice of the clinical pharmacist. The abnormal liver function and infection of the patient were gradually improved. Conclusion Clinicians ought to be alert to the changes of liver function when using latamoxef sodium for injection and do a better job of tracking and medication monitoring in order to ensure the safe use of drugs for patients.

Key words: latamoxef sodium for injection, liver function, adverse drug reaction