Abstract: Objective To analyze the adverse drug reactions (ADRs) caused by osteopeptide and compound osteopeptide injection in an area so as to provide reference for safe and rational use of drugs. Methods The 91 cases of adverse drug reactions associated with osteopeptide and compound osteopeptide injection collected between January 1, 2005 and October 31, 2019 in an area were analyzed retrospectively. Results Male patients outnumbered female ones (62.64% vs 37.36%). ADRs occurred regardless of age. More than half of the 91case reports involved glucose injection that was used as a solvent (52.75%). Most of the serious adverse events occurred within 30 minutes of medication (42.86%). Skin and appendage damage was the dominant clinical manifestation. Most of the patients were cured after treatment. Conclusion Osteopeptide and compound osteopeptide injection should be used in line with instructions. The conditions of patients should be closely observed within 30 minutes of medication in order to minimize adverse drug reactions.

Key words: osteopeptide, compound osteopeptide, injection, adverse drug reaction