Adverse Reactions of Visual Disturbances and Hallucinations Induced by Voriconazole Tablets in Two Cases and Related Literature Review

doi:10.19803/j.1672-8629.2021.06.20

Abstract

Abstract: Objective To summarize the regularity of such adverse reactions as visual disturbances and hallucination caused by voriconazole, and to provide reference for the safe and rational use of medicine by health care givers. Methods Two cases of visual disturbances and hallucinations caused by voriconazole in our hospital were reviewed. The chance, onset time, mechanism, correlations with blood concentration and outcomes of adverse reactions caused by voriconazole were studied. Results Voriconazole was more likely to cause visual toxicity and neurotoxic side effects than other antifungal drugs. Adverse reactions occurred mainly within the first five days of administration. There was a significant correlation between neurotoxicity and concentrations, but there was no significant correlation between visual toxicity and concentrations. Immediate discontinuation of the drug after the occurrence of adverse reactions could lead to good prognosis. Conclusion The adverse reactions to voriconazole mostly occur in the first five days of administration, and the prognosis is better if the drug is discontinued quickly.

Key words: voriconazole, visual disturbances and hallucinations, adverse drug reactions

CLC Number:

R994.11

ZHANG Xiaojuan, YANG Hongxin, GUO Xiaobin, JIE Peitao. Adverse Reactions of Visual Disturbances and Hallucinations Induced by Voriconazole Tablets in Two Cases and Related Literature Review[J]. Chinese Journal of Pharmacovigilance, 2021, 18(6): 588-591.

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