Early Warning of Risks of Statins in Atherosclerosis Therapy Based on Bioinformatics

doi:10.19803/j.1672-8629.2021.02.18

Abstract

Abstract: Objective To explore the potential safety risks of statins in the treatment of atherosclerosis based by bioinformatics. Methods The gene chip data GSE32547 in GEO database was retrieved by bioinformation technology. GO annotation, KEGG pathway analysis and protein interaction network analysis were conducted of the genes differentially expressed in HUVECs cells by statins to identify the safety risk of statins in the treatment of atherosclerosis. Results The results showed that the treatment of atherosclerosis with statins could be accompanied by skeletal muscle injuries and abnormalities in neurochemical conduction, thyroid metabolism, the respiratory system and fertility. Conclusion Statins can cause potential adverse reactions when used in the prevention and treatment of atherosclerosis. When statins are used for treating atherosclerosis, the condition of a patient's skeletal muscle deserves attention. When patients with skeletal muscle disease take statins, the risk/benefit to patients should be evaluated. Clinicians should be alert to safety risks to the nervous system, endocrine system, respiratory system and reproductive system.

Key words: statins, atherosclerosis, bioinformatics, risk warning

CLC Number:

R972.6

ZOU Lina, LIN Zhijian, ZHANG Xiaomeng, ZHANG Bing, HUANG Zhengkai. Early Warning of Risks of Statins in Atherosclerosis Therapy Based on Bioinformatics[J]. Chinese Journal of Pharmacovigilance, 2021, 18(2): 184-189.

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