Abstract: Objective To study the adverse drug reactions and influencing factors of cephalosporins in the perioperative period and seek targeted prevention in order to ensure the safety of patients.Methods A total of 246 medical records of patients with cephalosporins admitted to our hospital between January in 2017 and November in 2019 were randomly selected for retrospective analysis.Results The adverse drug reactions of cephalosporins involved the skin and accessory damage, digestive system damage, and central nervous system reactions. The main route of administration was intravenous injection and adverse drug reactions usually occurred within 1 hour of administration. There was statistically significant difference in the occurrence of adverse drug reactions between patients who were different in age, allergy history, concomitant medications, and routes of administration(P<0.05), but no significant difference was found in gender,weight or primary diseases between the ADR group and the non-ADR group (P>0.05).Conclusion Age above 60 years, a history of allergies, combined medications and intravenous administration are risk factors for adverse drug reactions of cephalosporins. During clinical medication, patients should be carefully evaluated for risk factors for adverse drug reactions to ensure the proper use of cephalosporins. Symptomatic treatment and rescue measures are critical to control of adverse drug reactions.

Key words: cephalosporins, antibacterial drugs, adverse drug reaction, influencing factor, analysis