157 Cases of Adverse Drug Reactions Induced by Iopromide Injection

doi:10.19803/j.1672-8629.2020.12.12

Abstract

Abstract: Objective To explore the clinical characteristics and regularity of adverse reactions (ADR) caused by iopromide injection so as to provide reference for reducing the risk of clinical medication.Methods The ADR reports of 157 cases of iopromide injection collected between 2009 and 2019 from the provincial database of the national adverse drug reaction monitoring system were statistically analyzed using the retrospective research method.Results ADRs caused by iopromide injection were more common among females than among males, and 68.16% of the ADRS occurred within 30 minutes of medication. The dominating clinical manifestations were the damage to the skin and its accessories, and anaphylactic shock was the most serious consequence.Conclusion In order to ensure the safety of drug use, drug instructions should be strictly observed clinically. Attention should be paid to the serious adverse reactions before and after drug use so as to identify and prevent ARDs as soon as possible and reduce the incidence of ADRs related to this injection.

Key words: lopromide injection, adverse drug reactions, rational drug application

CLC Number:

R994.11

CHENG Xiaoping, ZHU yajian, LIU Xueliang. 157 Cases of Adverse Drug Reactions Induced by Iopromide Injection[J]. Chinese Journal of Pharmacovigilance, 2020, 17(12): 904-906.

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https://www.zgywjj.com/EN/Y2020/V17/I12/904

References

[1] SFDA.SFDA issues information bulletin on adverse drug reactions-Beware of serious adverse reactions of iopromide injection and safflower injection[J].Shanghai Medical &Pharmaceutical Journal(上海医药),2013,34(5):61-62.
[2] Zhang MH,Wang JC.Retrospective analysis of 54 cases of adverse reactions of nonionic iodine contrast media in Jiaojiang District[J].Strait Pharmaceutical Journal(海峡药学),2020,32(6):222-224.
[3] Wang GJ,Sun QH,Chen HL,et al.Analysis of adverse reactions of iodine contrast agent in CT enhanced scanning[J].Chinese Journal of Pharmacovigilance(中国药物警戒),2020,17(4):235-238.
[4] Liu SY,Jin F.Literature analysis of 57 cases of adverse drug reactions of iopromide[J].Chinese Journal of Pharmacovigilance(中国药物警戒),2015,12(3):169-171.
[5] Li JX,Shi RH,Luo QQ,et al.Analysis of adverse reactions of iopromide in 32 cases[J].Pharmacy Today,2017,26(3):210-212.
[6] Liang MB,Wang GR.Literature analysis of 70 cases of adverse reactions caused by iopromide[J].China Pharmaceuticals(中国药业),2015,24(17):73-74.
[7] Liu HM,Wu QH,Wang J.Evaluation of Pareto analysis for adverse reactions of iodine contrast media[J].China Pharmaceuticals(中国药业),2019,28(24):90-92.
[8] Chen YD,Chen JY,Fu GS,et al.Chinese expert consensus on adverse reactions related to iodine contrast angiography[J].Chinese Journal of Interventional Cardiology(中国介入心脏病学杂志),2014,22(6):341-348.
[9] Tramer MR,von Elm E,Loubeyre P,et a1.Pharmacological prevention of serious anaphylactic reactions due to iodinated contrastmedia:systematic review[J].BMJ,2006,333(7570):675.
[10] Liu CH.Predictive value of iopromide allergy test on its adverse reactions[J].General Practice in China(中国全科医学),2018,11(13):1186-1187.
[11] He PG,Wang GP,Hou JY,et al.Study on the preventive value of iodine allergy test for adverse reactions of nonionic iodine contrast media[J].Journal of Practical Medical Techniques(实用医技杂志),2019,26(12):1536-1537.
[12] Wang TC,Du WM,Wang HM,et al.Logistic regression analysis of adverse reactions of nonionic iodine-containing contrast media[J].Chinese Journal of Pharmacoepidemiology(药物流行病学杂志),2008,17(3):167-169.
[13] Zhao L,Zhu SY,Xiang Y,et al.Delayed allergic reaction caused by iopromide:a case report[J].Chinese Journal of Hospital Pharmacy(中国医院药学杂志),2017,37(10):1000-1001.
[14] Cao YZ.Literature analysis of 15 cases of iodine contrast agent phase death[J].Central South Pharmacy(中南药学),2016,14(2):210-212.
[15] Pradubpongsa P,Dhana N,Jongjareamprasert K,et al.Adverse reactions to iodinated contrast media:prevalence,risk factors and results of a 3-year period[J].Asian Pac J Allergy Immanol,2013,31(4):299-306.
[16] Gao YJ.Function and safety analysis of common excipients for traditional Chinese medicine injection[J].Evaluation and Analysis of Drug Use in Hospitals of China,2014,14(7):640-642.
[17] Zhuang W,Liu YQ,Li YS,et al.Analysis of monitoring report on allergic reaction of iodine contrast medium during percutaneous coronary intervention in our hospital in the past 5 years[J]Chinese Journal of Pharmacovigilance(中国药物警戒),2013,10(12):734-736.
[18] He PG,Wang GP,Li H,et al.Prevention of adverse reactions of nonionic iodine contrast media by glucocorticoid before enhanced CT scanning[J].Practical Journal of Medicine &Pharmacy(实用医药杂志),2019,36(10):914-915.