Abstract: Objective To provide reference for safe use of polyene phosphatidyl- choline (PPC) in clinic by analyzing the literature about the adverse reactions of PPC. Methods Wanfang, Cqvip, CNKI, PubMed, Embase, Wiley, Springer, and Cochrane databases were searched online and the literature about adverse reactions (ADRs) caused by polyene phosphatidyl choline that was published between 2010 and 2019 was collected. Then, the data from the screened literature was analyzed. Results According to the screening criteria, 94 related articles were finally included involving a total of 718 subjects who had drug adverse reactions. The common adverse reactions of PPC were skin rash, nausea, vomiting, diarrhea, abdominal distension and loss of appetite. Most of the adverse reactions were relieved after symptomatic treatment or self-improved. Conclusion The oral preparations of PPC have proved to be safe and cause minor ADRs, but the risk posed by the injection deserves attention. Safe and rational application of PPC involves reinforcing standardized monitoring of PPC in the future.

Key words: polyene phosphatidyl choline, adverse reactions, gastrointestinal symptoms, skin rash, monitoring