Cases of Adverse Drug Reactions/events Induced by Diclofenac Sodium and Lidocaine Hydrochloride

doi:10.19803/j.1672-8629.2020.08.12

Chinese Journal of Pharmacovigilance ›› 2020, Vol. 17 ›› Issue (8): 508-512.
DOI: 10.19803/j.1672-8629.2020.08.12

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Cases of Adverse Drug Reactions/events Induced by Diclofenac Sodium and Lidocaine Hydrochloride

WU Wenli¹, LIU Jiani², LU Zhaogang¹, JIN jing¹, WANG Jian¹, WANG Jiyun¹, WANG Xiaoxu¹

¹Department of Clinical Pharmacy, People's Hospital of Ningxia Hui Autonomous Region /First Affiliated Hospital of Northwest University for Nationalities, Yinchuan Ningxia 750021, China;
²Department of Rehabilitation Medicine, People's Hospital of Ningxia Hui Autonomous Region/First Affiliated Hospital of Northwest University for Nationalities, Yinchuan Ningxia 750021, China

Received:2020-07-31 Revised:2020-07-31 Online:2020-08-15 Published:2020-07-31
Supported by:
宁夏科技惠民专项项目（2019CMG03008）: 他汀类药物合理应用与药学服务标准化示范

Abstract

Abstract: Objective To investigate the characteristics and regularities of adverse drug reactions/events (ADR/AE) induced by diclofenac sodium and lidocaine hydrochloride so as to provide reference for rational clinical use. Methods The data on 10 cases of ADR/AE induced by diclofenac sodium and lidocaine hydrochloride reported by a tertiary hospital in Ningxia Hui Autonomous Region and 8 cases from literature was analyzed retrospectively. The types of reports, gender, age, medical history, allergies, indications, times of occurrence, prognosis, systems or organs involved and clinical manifestations were analyzed. Results It was shown that the respiratory system and skin and its appendages were the most vulnerable. Patients with a previous asthma history had a high incidence of acute attack of asthma after medication. There were more severe cases of ADR/AE and death. ADRs occurred soon after administration of diclofenac sodium and lidocaine hydrochioride. Off-label drug use was commonplace. Conclusion The monitoring and rational use of diclofenac sodium and lidocaine hydrochloride should become a concern in order to prevent serious ADR/AE and ensure the safety of drug use.

Key words: diclofenac sodium and lidocaine hydrochioride, adverse drug reactions(ADR), adverse drug events(AE)

CLC Number:

R994.11

WU Wenli, LIU Jiani, LU Zhaogang, JIN jing, WANG Jian, WANG Jiyun, WANG Xiaoxu. Cases of Adverse Drug Reactions/events Induced by Diclofenac Sodium and Lidocaine Hydrochloride[J]. Chinese Journal of Pharmacovigilance, 2020, 17(8): 508-512.

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Cases of Adverse Drug Reactions/events Induced by Diclofenac Sodium and Lidocaine Hydrochloride

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