Research Progress of Weight Gain Induced by Antidepressants

doi:10.19803/j.1672-8629.2020.07.13

Abstract

Abstract: Objective Antidepressants, especially new antidepressants, are widely used, and the weight gain caused by them has been taken seriously into account. Methods Search the articles about weight gain caused by antidepressants published at home and abroad, and summarize the manifestations and reason of weight gain caused by antidepressants, and compare the effects of different drugs on weight, and look for prevention and treatment measures. Results Alot of antidepressants can lead to weight gain, especially in the second and third year. The most important reason is the increase of intake after blocking H1 receptor and 5-HT2C receptor. Mirtazapine has been supposed to causes the most weight gain, then SSRI and so on. Bupropion, wotexitin, verazolone and minopram did not gain weight. During the course of antidepressant treatment, weight gain can be solved by changing life style and replacement of drugs. Conclusion Doctors should pay attention to the possible weight gain when using antidepressants。It is improment to choose drugs reasonably,to inform and remind patients appropriately, to intervene in time after weight gain.

Key words: antidepressants, weight gain, reason, treatment measures

CLC Number:

ZHENG Xue, SI Jigang. Research Progress of Weight Gain Induced by Antidepressants[J]. Chinese Journal of Pharmacovigilance, 2020, 17(7): 444-447.

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