Abstract: Objective To study the clinical features, causal drugs and treatment of drug-induced liver injury(DILI) in children in order to contribute to rational drug application. Methods The clinical data on 70 children with DILI treated in Hunan Children's Hospital between January 2015 and May 2019 was analyzed. Results The ratio of males to females among these 70 cases was 2.04:1. Most of the children were aged 1 month to 1 year. Forty percent of the patients exhibited few apparent symptoms, except a few of them who exhibited fever, fatigue and poor appetite without specificity. Diagnosis suggested that most of these patients suffered from hepatocellular liver injury (28.57%), cholestasis liver injury (28.57%) or mixed liver injury (18.57%). Among these cases, 21 (24.29%) were induced by antipyretic analgesics, 13 (24.29%) by antimicrobials and 12 (17.14%) by antiviral drugs. Bifendate, glutathione and diisopropylamine dichloroacetate were commonly used drugs for DILI patients. Sixty-six of these cases (94.29%) were treated with two or more types of drugs. Moreover, improper drug use was observed, such as wrong usage and dosage of biphenyl diester, wrong solvents of glycyrrhizin and polyene phosphatidylcholine injection, and inappropriate concentrations of potassium and magnesium aspartate. Conclusion Overdose of antipyretic and analgesic drugs, antibacterial drugs and antiviral drugs in patients can result in significant hepatotoxicity. Clinicians should carefully select drugs and treat DILI children with drugs according to the instructions.

Key words: drug-induced liver injury, clinical features, rational drug use, children