Abstract: ObjectiveTo investigate the characteristics of serious adverse drug reactions (ADRs) associated with eight types of atypical antipsychotics in order to provide reference for safe and rational use of drugs in clinic. Methods There were 1 497 serious ADRs induced by clozapine, risperidone, olanzapine, quetiapine, ammonia, ziprasidone, aripiprazole and paliperidone as reported by Zhejiang ADR monitoring system from January 2015 to April 2019. These ADRs were analyzed by using Excel software. Results These serious ADRs caused by different atypical antipsychotic drugs varied, the most common of which involved damage to the liver and biliary system and to the neurological system. However, some ADRs were unique to certain drugs. For example, paliperidone led to reproductive disorders, clozapine blood disorders, ammonia damage to the endocrine system, and aripiprazole led to urinary tract disorders. Conclusion ADRs caused by atypical antipsychotic drugs are wide-spread. It’s important to strengthen the monitoring of serious ADRs by such means as a regular follow-up of liver function and B ultrasound. In addition, more attention should be paid to unique ADRs of different drugs. Doctors should prescribe drugs with reference to the patients' preexisting diseases.

Key words: atypical antipsychotic drugs, serious adverse drug reactions, reports, monitoring