Abstract: Objective To explore the characteristics and profiles of adverse drug reactions (ADRs) caused by HPV vaccination, in order to provide reference basis for the safety use promotion of HPV vaccines. Methods From January 2018 to December 2018, bivalent or quadrivalence human papillomavirus (HPV) vaccines were administered to eligible women. Local and systemic reactions that occurred within fifteen days of half a month after vaccination were recorded. Results Most of the 732 recipients of HPV vaccination were recipients, married women and urban women were the main ones. Women aged 30 to 39 accounted for a large proportion. In the previous year, less than 50% of married women completed cervical cancer screening or and human papillomavirus screening. Local adverse reactions were dominating the main, followed by dizziness, headache, digestive tract symptoms and fever. No serious adverse reactions were found. Conclusion The clinical safety of HPV vaccination is safe clinically better. In view of the adverse reactions induced by of vaccines, corresponding precautions should be taken preventive measures should be for mulated to reduce the occurrence of adverse reactions. At the same time, we should strengthen the propaganda and education of cervical cancer knowledge for rural women and unmarried women should be better informed of, so that they can fully understand

Key words: human papillomavirus vaccine, adverse drug reactions, influencing factor