Abstract: Objective To analyze the adverse reactions(ADRs) induced by combination of pantoprazole, Puyuan Hewei and Bailemian Capsules, providing references for clinical safety and rational use of drugs. Methods A case admitted in Department of Dermatology, the Affiliated Hospital of Qingdao University at March 2019 was study who appeard Henoch-Schonlein Purpura after using a combination of pantoprazole, Puyuan Hewei and Bailemian Capsules to analyze the clinical manifestations of ADRs. Results The patient' chief complaints were ecchymosis and petechia at duoble lambs for 5 days. 5 days ago, the patient oral a combination of pantoprazole, Puyuan Hewei and Bailemian Capsules because of abdominal pain. After 1 hour of drugs administration, duoble lambs appeared ecchymosis and petechia. Then the patient diagnosed with Henoch-Schonlein Purpura. The lesions completely subsided after 3 weeks of anti-allergic treatment. Conclusion Henoch-Schonlein Purpura induced by pantoprazole may be 'class effect' of PPIs due to their substituted benzimidazole structure, but we cannot rule out the possibility that the adverse drug reaction induce by Puyuan Hewei or Bailemian Capsules.We should be more careful when using combination of modem and traditional medicines.

Key words: Pantoprazole, Puyuan Hewei Capsules, Bailemian Capsules, Henoch-Schonlein Purpura