中国药物警戒 ›› 2014, Vol. 11 ›› Issue (9): 521-523.

• 基础研究 • 上一篇    下一篇

雷公藤片和雷公藤多苷片抗炎作用量效研究

冯群1 孙蓉 2*, 孙晓倩3   

  1. 1天津中医药大学,天津300073;
    2山东省中医药研究院,山东 济南250014;
    3山东中医药大学,山东 济南250355
  • 收稿日期:2014-07-16 修回日期:2016-02-03 出版日期:2014-09-08 发布日期:2016-03-02
  • 通讯作者: 孙蓉,女,研究员,博士生导师,中药药理与毒理研究。E-mail：sunrong107@163.com
  • 作者简介:冯群,男,在读硕士,中药药理与毒理研究。
  • 基金资助:
    基金项目：国家重点基础研究发展计划（973）中医基础理论专项资助项目2（2009CB522802）

Research of Dose-efficacy on Suppression of Tripterygium Wilfordii Tablets and Tripterygium Wilfordii Polyglycoside Tablets on Acute Inflammation

FENG Qun1, SUN Rong2, *, SUN Xiao-qian3   

  1. 1Tianjin University of Traditional Chinese Medicine, Tianjin 300073, China;
    2Shandong Academy of Chinese Medicine, Shandong Jinan 250014, China;
    3Shandong University of Traditional Chinese Medicine, Shandong Jinan 250355, China
  • Received:2014-07-16 Revised:2016-02-03 Online:2014-09-08 Published:2016-03-02

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摘要： 目的明确雷公藤片和雷公藤多苷片发挥抗炎作用的剂量范围,比较其作用效果异同,为临床用药提供依据。方法给小鼠灌胃不同量的雷公藤片和雷公藤多苷片,连续3天,通过巴豆油混合致炎液致小鼠耳肿胀模型计算雷公藤片和雷公藤多 苷片对抗急性炎症的半数有效量（ED50）,探讨雷公藤片和雷公藤多 片对小鼠急性炎症的抑制作用差异。结果雷公藤片和雷公藤多 苷片发挥抗炎作用的ED50分别为17.753 μg·kg-1和9.236 mg·kg-1,折合成雷公藤甲素分别为17.753和8.922 μg·kg-1,分别相当于临床70 kg人临床日用量的20.30倍和10.21倍。结论雷公藤片、雷公藤多苷片均可拮抗巴豆油混合致炎液导致的急性炎症,且呈现良好的量效关系。抗炎作用强度为雷公藤多 苷片>雷公藤片。提示雷公藤甲素、雷公藤多苷均是雷公藤抗炎作用的物质基础。雷公藤抗炎作用机制有待于进一步研究。

关键词: 雷公藤片, 雷公藤多苷片, 雷公藤甲素, 抗炎作用

Abstract: ObjectiveTo explore the dose range of anti-inflammatory effect of Tripterygium wilfordii tablets (TWT) and Tripterygium wilfordii polyglycoside (TWP)tablets and compare with the results of them, so as to provide the basis for clinical medication. MethodsMice were respectively given the different doses of TWT and TWP for 3 consecutive days by gavage. The anti-inflammatory effects of TWT and TWP were explored according to the model of ear edema by mixture of compound croton oil we made. ED50 and ED95 of anti-inflammatory efficacy and LD50 and LD5 of acute toxicity test were calculated. ResultsED50 and 95% confidence limit of TWT and TWP were respectively 17.753 (13.567~21.448) μg·kg-1, 9.236 (5.570~ 11.915) mg·kg-1, which were equal to triptolide of 17.753 μg·kg-1, 8.922 μg·kg-1. They were respectively equal to 20.30 and 10.21 times of 70 kg person's daily dried medicine expenses. ConclusionTWT and TWP show good suppression on the acute inflammation caused by mixture of compound croton oil. The potency of TWP is better than that of TWT. Triptolide with good effect of anti-inflammation shows a good "dose-effect" relationship. But it is not the only material basis of Tripterygium wilfordii for anti-inflammatory effect. The effective dose ranges of them show a certain dose-effect relationship. The mechanism of anti-inflammatory effect needs a further study.

Key words: Tripterygium wilfordii tablets, Tripterygium wilfordii polyglycoside tablets, triptolide, anti-inflammatory effect

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