中国药物警戒 ›› 2026, Vol. 23 ›› Issue (6): 699-701.
DOI: 10.19803/j.1672-8629.20260104

• 安全与合理用药 • 上一篇    下一篇

肤痔清软膏致下肢水肿1例分析

王浩1, 潘澎2, 秦海军2, 王建平3,*   

  1. 1国家药品监督管理局药品评价中心,国家药品监督管理局监管科学创新研究基地,北京 100163;
    2中国人民解放军空军特色医学中心中医科,北京 100142;
    3中国人民解放军空军特色医学中心药剂科,北京 100142
  • 收稿日期:2026-02-03 出版日期:2026-06-15 发布日期:2026-06-18
  • 通讯作者: *王建平,男,硕士,副主任药师,医院药学。E-mail: wang-jianping@163.com
  • 作者简介:王浩,男,在读博士,主管药师,老年医学。

One Case of Lower Limb Edema Caused by Fuzhiqing Ointment

WANG Hao1, PAN Peng2, QIN Haijun2, WANG Jianping3,*   

  1. 1Center for Drug Reevaluation, NMPA/NMPA Center for Innovation and Research in Regulatory Science, Beijing 100163, China;
    2Department of Traditional Chinese Medicine, Air Force Medical Center, Beijing 100142, China;
    3Department of Pharmacy, Air Force Medical Center, Beijing 100142, China
  • Received:2026-02-03 Online:2026-06-15 Published:2026-06-18

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摘要： 目的 探讨肤痔清软膏致下肢水肿的不良反应,为临床使用肤痔清软膏提供参考。方法 分析1例脑梗患者伴混合痔、血栓性外痔、便秘、慢性肛管直肠炎,外用肤痔清软膏12 d后发生下肢水肿,讨论不良反应发生原因及防治措施。结果 经关联性评价,患者发生下肢水肿很可能与较长时间使用肤痔清软膏有关。停药2 d后患者症状好转,停药1周后症状消失。结论 临床长期使用肤痔清软膏需注意下肢水肿不良反应的发生风险,合理使用该药品。

关键词: 肤痔清软膏, 混合痔, 下肢水肿, 药品不良反应

Abstract: Objective To explore the adverse reactions induced by Fuzhiqing ointment and provide a reference for its clinical application. Methods One case of a patient with cerebral infarction complicated with mixed hemorrhoids, thrombotic external hemorrhoids, constipation, and chronic anorectal inflammation was analyzed. The patient developed bilateral lower limb edema after 12 days of topical application of Fuzhiqing ointment. The possible causes, as well as corresponding prevention and treatment measures, were explored. Results The lower limb edema in this patient was likely associated with the prolonged topical use of Fuzhiqing ointment. The symptoms of the patient improved significantly 2 days after drug withdrawal and completely disappeared one week after drug withdrawal. Conclusion Clinicians should be alert to the risk of lower limb edema among patients who chronically use Fuzhiqing ointment, and ensure its rational use.

Key words: Fuzhiqing Ointment, Mixed Hemorrhoids, Lower Limb Edema, Adverse Drug Reaction

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