中国药物警戒 ›› 2026, Vol. 23 ›› Issue (3): 340-342.
DOI: 10.19803/j.1672-8629.20250185

• 安全与合理用药 • 上一篇    下一篇

结核菌素纯蛋白衍生物致过敏性休克1例分析

李佳希1, 雷晓天1, 赵科1, 牛丽1, 孙阳1, 钟怀乐1, 郭浩1,2,*   

  1. 1内蒙古自治区人民医院药学处,内蒙古 呼和浩特 010010;
    2内蒙古自治区基本药物监测与临床综合评价中心,内蒙古 呼和浩特 010010
  • 收稿日期:2025-03-27 出版日期:2026-03-15 发布日期:2026-03-17
  • 通讯作者: *郭浩,男,博士,主任药师,循证药学。E-mail: guohao19870323@yeah.net
  • 作者简介:李佳希,女,硕士,主管药师,医院药学。

One Case of Anaphylactic Shock Caused by Purified Protein Derivative of Tuberculin

LI Jiaxi1, LEI Xiaotian1, ZHAO Ke1, NIU Li1, SUN Yang1, ZHONG Huaile1, GUO Hao1,2,*   

  1. 1Department of Pharmacy, Inner Mongolia People’s Hospital, Hohhot Inner Mongolia 010010, China;
    2Inner Mongolia Autonomous Region Centre for Monitoring and Comprehensive Clinical Evaluation of Essential Drugs, Hohhot Inner Mongolia 010010, China
  • Received:2025-03-27 Online:2026-03-15 Published:2026-03-17

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摘要： 目的 探讨结核菌素纯蛋白衍生物（TB-PPD）致过敏性休克的特点及机制,以提高用药安全性。方法 分析1例行结核菌素皮肤试验的10岁患儿,皮内注射TB-PPD致过敏性休克病例,并结合文献分析其发病机制。结果 关联性评价显示,本例患儿发生过敏性休克很可能为TB-PPD所致。经抗过敏及对症处理后转归良好。结论 过敏性休克起病迅速并可能危及生命,是TB-PPD罕见但严重的不良反应,用药期间应密切关注患者,警惕该不良反应的发生。

关键词: 结核菌素纯蛋白衍生物, 结核菌素, 过敏性休克, 药品不良反应

Abstract: Objective To investigate the characteristics and mechanisms of anaphylactic shock caused by a purified protein derivative of tuberculin (TB-PPD) in order to ensure the safety of medication. Methods The clinical data of a 10-year-old patient was studied, who had experienced anaphylactic shock following an intradermal injection of TB-PPD during a tuberculin skin test. The underlying mechanisms were analyzed based on related literature. Results According to correlation analysis, it was concluded that the allergic shock experienced by the patient was likely caused by TB-PPD. After anti-allergic and symptomatic treatment, the patient recovered. Conclusion Anaphylactic shock has rapid onset and may be life-threatening, which is a rare but severe adverse reaction linked to TB-PPD. Close monitoring of patients is essential during treatment to prevent this adverse reaction.

Key words: Purified Protein Derivative of Tuberculin (TB-PPD), Tuberculin, Anaphylactic Shock, Adverse Drug Reaction

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