注射用头孢哌酮钠舒巴坦钠联用去乙酰毛花苷注射液致双硫仑样反应1例分析

doi:10.19803/j.1672-8629.20250154

中国药物警戒 ›› 2026, Vol. 23 ›› Issue (3): 337-339.
DOI: 10.19803/j.1672-8629.20250154

注射用头孢哌酮钠舒巴坦钠联用去乙酰毛花苷注射液致双硫仑样反应1例分析

王蕾, 张立超, 钱凤丹^*

上海中医药大学附属市中医医院药学部,上海 200071

收稿日期:2025-03-14 出版日期:2026-03-15 发布日期:2026-03-17
通讯作者: ^*钱凤丹,女,硕士,副主任药师,临床药学。E-mail: qianfengdan@126.com
作者简介:王蕾,女,硕士,药师,临床药学。
基金资助:
市级医院诊疗技术推广及优化管理项目资助（SHDC22024202）

One Case of Disulfiram-Like Reactions Caused by Cefoperazone Sodium and Sulbactam Sodium for Injection Combined with Deslanoside Injection

WANG Lei, ZHANG Lichao, QIAN Fengdan^*

Department of Pharmacy, Hospital of Traditional Chinese Medicine Affiliated to Shanghai University of Chinese Medicine, Shanghai 200071, China

Received:2025-03-14 Online:2026-03-15 Published:2026-03-17

摘要/Abstract

摘要： 目的探讨双硫仑结构类似的药物与辅料中含有乙醇的药物合并用药安全性。方法分析1例使用注射用头孢哌酮钠舒巴坦钠联用去乙酰毛花苷注射液后出现双硫仑样反应的病例,并查阅国内外相关文献对双硫仑样反应进行探讨。结果经关联性分析,患者发生双硫仑样反应（轻度心率增快、寒战、面部潮红、出汗等症状）与去乙酰毛花苷注射液和注射用头孢哌酮钠舒巴坦钠联用有关,经停药及对症处理后,症状好转。结论辅料中含乙醇的药物与头孢类抗生素联用可能导致双硫仑样反应。严重的双硫仑样反应可引起意识障碍、昏厥、休克甚至死亡。临床应重视,在高危人群中使用辅料含乙醇的药物时,应加强用药前的评估和用药时的监测,避免发生严重的双硫仑样反应,保障患者用药安全。

关键词: 头孢哌酮钠舒巴坦钠, 去乙酰毛花苷, 双硫仑样反应, 药品不良反应

Abstract: Objective To investigate the safety of drugs with similar structure to disulfiram and combined with drugs containing ethanol as excipients. Methods One case of disulfiram-like reactions after using cefoperazone sodium and sulbactam sodium for injection combined with deslanoside injection was analyzed before the disulfiram-like reactions were explored based on literature at home and abroad. Results The patient was given intravenous drips of deslanoside injection, cefoperazone sodium and sulbactam sodium for injection. After 12 minutes, the patient began to show a mild increase of heart rate, chills, facial flushing, sweating and other symptoms. After withdrawal of medication and symptomatic treatment, these symptoms were alleviated. Conclusion The combination of ethanol-containing excipients and cephalosporin antibiotics may lead to disulfiram-like reactions that, in severe cases, can cause disturbance of consciousness, fainting, shock and death. Clinicians should be cautious in using excipients containing ethanol in high-risk groups, make careful assessments before medication and monitor patients in order to prevent serious disulfiram-like reactions.

Key words: Cefoperazone Sodium and Sulbactam Sodium, Deslanoside, Disulfiram-Like Reaction, Adverse Drug Reaction

中图分类号:

R978
R994.11

王蕾, 张立超, 钱凤丹. 注射用头孢哌酮钠舒巴坦钠联用去乙酰毛花苷注射液致双硫仑样反应1例分析[J]. 中国药物警戒, 2026, 23(3): 337-339.

WANG Lei, ZHANG Lichao, QIAN Fengdan. One Case of Disulfiram-Like Reactions Caused by Cefoperazone Sodium and Sulbactam Sodium for Injection Combined with Deslanoside Injection[J]. Chinese Journal of Pharmacovigilance, 2026, 23(3): 337-339.

导出引用管理器 EndNote|Ris|BibTeX

链接本文: https://zgywjj.magtechjournal.com/CN/10.19803/j.1672-8629.20250154

https://zgywjj.magtechjournal.com/CN/Y2026/V23/I3/337

参考文献

[1] LI YG, LIU CY, ZHANG W, et al.Study on the Mechanism of Disulfiram-Like Reaction Caused by Cephalosporins with Different Structures[J]. Journal of Forensic Medicine(中国法医学杂志), 2024, 39(2): 192-195, 202.
[2] XU XX, HE WK, WANG Y, et al.Analysis of Disulfiram-Like Reaction Caused by Chinese Patent Medicine[J]. Pharmaceutical Journal of Chinese People’s Liberation Army(解放军药学学报), 2023, 36(6): 560-561.
[3] LU H, SHI QZ, LIU FQ.The Combination of Cefoperazone Sodium and Sulbactam Sodium for Injection and Compound Licorice Oral Solution Induced Disulfiram-Like Reaction: One Case[J]. Central South Pharmacy(中南药学), 2017, 15(12): 1802.
[4] ZHANG WJ, FENG YN, ZHUANG W, et al.A Literature Review of Herb-Induced Disulfiram-Like[J]. Chinese Journal of Rational Drug Use(中国合理用药探索), 2024, 21(12): 103-110.
[5] ZHANG ZZ, ZHU J.Hydroprednisone Injection Combined with Cephalosporins-Induced Disulfiram-Like Reaction: one Case[J]. China Pharmacist(中国药师), 2015(11): 1955-1955.
[6] TAN YY, FENG YN, HAN Q, et al.Pharmaceutical Monitoring of Disulfiram-Like Reactions Caused by Voriconazole Combined with Cefoperazone Sodium Sulbactam Sodium: one Case[J]. Chinese Journal of Clinical Rational Drug Use(临床合理用药), 2024, 17(20): 169-172.
[7] ZHANG Q, LIANG HY, JIANG ZH.Dose-Response Analysis of Disulfiram-Like Reaction Caused by Calosporins and Ethanol Use[J]. Pharmaceutical Journal of Chinese People’s Liberation Army(解放军药学学报), 2025, 38(3): 227-223.
[8] LI YG.Research on the Mechanism of Cefalosporin-Induced Disulfiram-Like Reaction Based on Hepatic AD and ALDH Activity and Brain 5-HT levels[D]. Shanxi: Shanxi Medical University, 2024.
[9] ZHANG Y.Analysis of Influencing Factors of Drug-Induced Disulfiram-Like Reaction Susceptibility Period and Disease Severity[J]. Modern Medical Journal(现代医学), 2016, 44(7): 999-1001.
[10] SHU JW, QIAN XD, JIANG YC.Current Situation and Safety Analysis of Pharmaceuticals Containing Alcohol Excipients ICU[J]. Chinese Journal of Drug Abuse Prevention and Treatment(中国药物滥用防治杂志), 2023, 29(9): 1533-1536.
[11] ZHANG L.Literature Analysis of 27 Cases of Adverse Reactions Caused by Compound Licorice Mixture/Oral Solution[J]. China Pharmacy(中国药房), 2015, 26(24): 3361-3363.
[12] CEN GX, JIANG P, PENG H, et al.Clinical Analysis of 30 Cases of Disulfiram-Like Reactions Caused by Cefoperazone Sulbactam Sodium in Elderly People After Drinking[J]. Practical Geriatrics(实用老年医学), 2011, 25(6): 528.
[13] BAI J, ZHANG Y, LI MM, et al.Research Hotspots and Frontier Trend Analysis of Disulfiram-Like Based on Bibliometrics[J]. Chinese Journal of Rational Drug Use(中国合理用药探索), 2024, 21(12): 18.
[14] LUO K.Effect Analysis of the Combination of Naloxone and Dexamethasone in the Treatment of Disulfiram-Like Reaction[J]. China Practical Medicine(中国实用医药), 2016, 11(9): 150-151.

[1]	秦博, 李根, 杜宇, 高山, 兰姗, 彭丹, 江永贤. 某省未成年人群应用阿奇霉素安全性风险分析[J]. 中国药物警戒, 2026, 23(3): 302-306.
[2]	蒋艳林, 邓俊刚, 陈薇, 张晶晶, 方春霞, 覃忠于, 彭英知, 郭冰, 廖儒佳. 注射用卡瑞利珠单抗致严重不良反应及风险因素分析[J]. 中国药物警戒, 2026, 23(3): 307-311.
[3]	黄丽, 张了云, 付敏, 李根, 杜宇, 高山, 兰姗, 彭丹, 江永贤. 209例尖吻蝮蛇血凝酶不良反应报告分析[J]. 中国药物警戒, 2026, 23(3): 312-317.
[4]	王雨婷, 朱芳仪, 吕欣鸽, 潘晨, 武一, 崔向丽. 免疫检查点抑制剂致肠炎病例分析[J]. 中国药物警戒, 2026, 23(3): 318-322.
[5]	栗玉杰, 马健桐, 张文静, 郭浩. 注射用伏立康唑不良反应特征及危险因素分析[J]. 中国药物警戒, 2026, 23(3): 323-327.
[6]	吉柳, 郝敏, 武文慧. 注射用紫杉醇脂质体致乙二胺四乙酸依赖性假性血小板减少症1例分析[J]. 中国药物警戒, 2026, 23(3): 334-336.
[7]	李佳希, 雷晓天, 赵科, 牛丽, 孙阳, 钟怀乐, 郭浩. 结核菌素纯蛋白衍生物致过敏性休克1例分析[J]. 中国药物警戒, 2026, 23(3): 340-342.
[8]	曹阳, 付晓秀, 马林. 盐酸替罗非班氯化钠注射液致血栓性血小板减少性紫癜1例分析[J]. 中国药物警戒, 2026, 23(3): 346-348.
[9]	龙欢, 王凯鑫, 杨悦琦, 安明惠, 梁雨薇, 刘红冉, 高旭, 张丽, 丁佳欣, 宫建. 辐射防治药物警戒研究[J]. 中国药物警戒, 2026, 23(3): 355-360.
[10]	王春婷, 张瑞芳, 陈亚飞. 盐酸雷尼替丁注射制剂安全性风险分析[J]. 中国药物警戒, 2026, 23(2): 181-184.
[11]	田春雨, 夏玉朝, 张艳华, 尹月. 达拉非尼胶囊联合曲美替尼片致发热综合征的分析[J]. 中国药物警戒, 2026, 23(2): 192-196.
[12]	江文豪, 徐红冰, 张小刚, 吴江平. 盐酸胺碘酮注射液致急性肝衰竭1例分析[J]. 中国药物警戒, 2026, 23(2): 197-199.
[13]	于凌子, 贺嘉捷, 平娜娜, 朱倩, 张晓, 李俊红, 邹瑞, 何思蕴, 夏凡, 金正明, 曲昌菊. 格菲妥单抗注射液致免疫相关心肌损伤1例分析[J]. 中国药物警戒, 2026, 23(2): 200-202.
[14]	刘甜甜, 靳梦亚, 赵雪, 巩颖, 张彦丽, 曹俊岭. 注射用美罗培南与伏立康唑联用致严重精神障碍1例分析[J]. 中国药物警戒, 2026, 23(2): 203-206.
[15]	孟德辉, 王超, 李华, 丁春雷. 替吉奥胶囊致胃癌患者重症间质性肺炎1例分析[J]. 中国药物警戒, 2026, 23(2): 207-209.

注射用头孢哌酮钠舒巴坦钠联用去乙酰毛花苷注射液致双硫仑样反应1例分析

One Case of Disulfiram-Like Reactions Caused by Cefoperazone Sodium and Sulbactam Sodium for Injection Combined with Deslanoside Injection

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics