中国药物警戒 ›› 2012, Vol. 9 ›› Issue (11): 691-692.

• 药械安全性研究 • 上一篇    下一篇

84例奈达铂致不良反应分析

陈颖1, 林昊2   

  1. 1 广西梧州市红十字会医院临床药学科,广西 梧州 543002；
    2 广西梧州食品药品检验所,广西 梧州 543000
  • 收稿日期:2012-05-29 出版日期:2012-11-10 发布日期:2015-08-07
  • 作者简介:陈颖,女,主管药师,临床药学。

Analysis of 84 Cases of Adverse Reaction Induced by Nedaplatin

CHEN Ying1, LIN Hao2   

  1. 1 Dept. of Clinical Medicine, Guangxi Wuzhou Red Cross Hospital, Guangxi Wuzhou, 543002, China;
    2 Guangxi Wuzhou Institute for Food and Drug Control, Guangxi Wuzhou, 543000, China
  • Received:2012-05-29 Online:2012-11-10 Published:2015-08-07

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摘要： 目的通过对 84例奈达铂致不良反应（ADR）的病例进行分析,探讨其引起不良反应的规律和原因,为临床合理用药提供参考。方法对2004~2011年广西区药品不良反应网络管理平台提取奈达铂致ADR病例报告84例,分别从患者性别、年龄、原患疾病、用药剂量、涉及器官或系统及临床表现等方面进行统计、分析。结果84份ADR报告中,51~60岁的患者ADR发生率最高（占31.3%）,ADR最为常见的临床表现为神经系统损害（占41.1%）,其次为呼吸系统（占32.1%）以及皮肤及其附件（占28.6%）损害。结论应加强医务人员对奈达铂致ADR的上报意识,分析ADR的发生特点,确保临床安全,减少或避免ADR的发生。

关键词: 奈达铂, 药品不良反应, 分析

Abstract: ObjectiveThrough analysing 84 ADR cases of the nedaplatin to explore the rules and causes of adverse reactions, provide a reference for clinical rational use of drugs. MethodsOn the basis of the adverse drug reaction network management platform in Guangxi Zhuang Autonomous Region, 84 cases of ADR reports caused by nedaplatin from 2004 to 2011 were analyzed in terms of the gender, age, primary disease, doses, system-organs involved, clinical manifestation. ResultsAmong 84 ADR reports, highest rate of ADR occurred in patients with 51~60 years old(31.3%), the most common ADRs were nervous system injury(41.1%), followed by respiratory system injury(32.1%) and skin and appendages injury(28.6%). ConclusionMedical personnel should raise the awareness of reporting ADR of nedaplatin, analyze its characteristics, so as to ensure clinical safety, reduce or avoid the occurrence of ADR.

Key words: nedaplatin, adverse drug reactions, analyse