基于蒙医药学古籍文献探析蒙药药物警戒科学内涵

doi:10.19803/j.1672-8629.20230743

摘要/Abstract

摘要： 目的从药物警戒角度对蒙医药学古籍文献进行研究,阐释蒙药药物警戒理论内涵,为深入开展蒙药安全性评价与蒙药药物警戒研究提供参考。方法通过梳理4世纪以来40余本蒙医药学经典著作及史籍文献,挖掘其中蕴含的药物警戒内容,分析蒙医药学毒性理论及安全合理用药特点。结果蒙医药学重视药物两重性,即药物在治疗疾病的同时也会给人体带来危害。蒙药药物警戒主要体现在毒的认识,中毒解毒,饮食禁忌、起居禁忌、体质禁忌、疾病禁忌等用药禁忌,配伍、炮制等减毒方法,药物剂量、疗程的控制原则及剂型特点等方面。结论蒙古族对“毒”的认识和使用历史悠久,加之蒙医药学理论特点和临床用药区别,安全合理用药实践内容丰富且独具特色。挖掘蒙药药物警戒科学内涵,对指导现代临床合理使用蒙药和传承传统医药学都具有现实和深远意义。

关键词: 蒙药, 古籍, 药物警戒, 药品不良反应, 毒, 用药禁忌, 配伍, 炮制

Abstract: Objective To study the ancient Mongolian Medical literature from the perspective of pharmacovigilance, explain the theoretical connotation of Mongolian Medicine pharmacovigilance, and provide a reference for further research on the safety evaluation and pharmacovigilance of Mongolian Medicine. Methods By combing through over 40 classic works of Mongolian Medicine and historical documents since the 4th century, the content related to pharmacovigilance was excavated, and the toxicity theory and characteristics of safe and rational drug use in Mongolian Medicine were analyzed. Results The study found that Mongolian Medicine attaches great importance to the duality of drugs, which means that drugs can bring harm to the human body while treating diseases. The Mongolian Medicine pharmacovigilance is mainly reflected in the following aspects: the understanding of toxicity, detoxification of poisoning, dietary taboos, living taboos, physical taboos, disease taboos, and other medication taboos; methods of reducing toxicity such as compatibility and processing; principles for controlling drug dosage and treatment duration; as well as the characteristics of dosage forms. Conclusion Mongolian people have a long history of understanding and using “toxicity”, coupled with the theoretical characteristics of Mongolian Medicine and clinical medication differences, the practice of safe and rational drug use is rich and unique. Exploring the scientific connotation of Mongolian Medicine pharmacovigilance has practical and far-reaching significance for guiding the rational use of Mongolian Medicine in modern clinical practice and inheriting traditional medicine.

Key words: Mongolian Medicine, ancient books, pharmacovigilance, adverse drug reaction, toxicity, compatibility, processing

中图分类号:

阿拉腾花, 高磊, 张晓朦, 张冰. 基于蒙医药学古籍文献探析蒙药药物警戒科学内涵[J]. 中国药物警戒, 2024, 21(6): 677-682.

ALATENG Hua, GAO Lei, ZHANG Xiaomeng, ZHANG Bing. Exploring the scientific connotation of Mongolian Medicine pharmacovigilance based on ancient Mongolian Medical literature[J]. Chinese Journal of Pharmacovigilance, 2024, 21(6): 677-682.

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参考文献

[1] XIAO XH, BAI ZF, WANG JB, et al.Traditional Chinese medicine (TCM) safety evaluation and pharmacovigilance[J]. Chinese Science Bulletin(科学通报), 2021, 66(Z1): 407-414.
[2] SPRINGER VIENNA.WHO collaborating centre for international drug monitoring[J]. Dictionary Pharm Med, 2009, 1534(1): 193.
[3] XIA DS, TIAN CH, WANG T.Changes of drug regulatory concepts in evidenced by enactment and revision of the drug administration law[J]. Chinese Journal of Pharmacovigilance(中国药物警戒), 2021, 18(9): 837-844.
[4] NMPA. National Medical Products Administration Announcement on the Publication of“Code for Quality Management of Pharmacovigilance”(No. 65 of2021)[EB/OL]. (2021-05-13)[2023-7-01]. https://www.nmpa.gov.cn/yaopin/ypggtg/20210513151827179.html.
[5] ZHANG B, LYU JT, ZHANG XM, et al.Traditional Chinese medicine property-based understanding of toxicity, efficacy and pharmacovigilance[J]. Chinese Journal of Pharmacovigilance(中国药物警戒), 2021, 18(5): 411-415.
[6] WEI SHOU(Beiqi). The History of Wei: Biography of Hun Yu Wen Mo Huai(匈奴宇文莫槐传)[M]. Beijing: Zhonghua Book Company, 1974: 2304.
[7] LI F.XIA JQ, edited and collated. Tai Ping Yu Lan (太平御览) [M]. Shijiazhuang: Hebei Education Publishing House, 1994: 115.
[8] B·JIGMED. Survey on the three classic works of Mongolian Medicine[J]. Chinese Mongolian Medicine (Mongolian)(中国蒙医药蒙), 2006, 1(1): 9-15.
[9] B·JIGMED. The review of the classical works of Mongolian Medicine[J]. Chinese Journal of Medicine(中国医药学报), 1988, 1(3): 33-34.
[10] SONGBAKANBU·YIXIBALJOR. The Editorial Committee of Mongolian Medical Classics compiled and translated. The Four Treatises on Nectar: Mongolian (甘露四部:蒙古文)[M]. Hohhot: Inner Mongolia People’s House, 2014:6-480.
[11] LOBUSANGQUEYINPEILE. The department of Traditional Chinese and Mongolian Medicine of Inner Mongolia Medical College compiled.Burenbatu,Temuribagen edited and annotated. Zheduiningnuoer: Mongolian(哲对宁诺尔:蒙古文 )[M]. Chifeng: Inner Mongolia Science and Technology publishing House, 2015: 314-518.
[12] GE H (Jin Dynasty). Bu Ji Zhou Hou Fang(补辑肘后方) [M]. Hefei: Anhui Science and Technology Publishing House, 1983:118.
[13] SUN SM (Tang Dynasty). Qian Jin Fang (千金方)[M]. Beijing: China Press of Traditional Chinese Medicine, 1998: 275, 285.
[14] TANBAKANGLAI (Japan). Yi Xin Fang (Chinese)(医心方中)[M]. Shenyang: Liaoning Science and Technology House, 1996: 418-419.
[15] SU S (Song Dynasty). Tu Jing Ben Cao(图经本草)[M]. Fuzhou: Fujian Science and Technology Publishing House, 1988: 51.
[16] ZHEN Q (Tang Dynasty). Gu jin Lu Yan Fang(古今录验方)[M]. Beijing: China Medical Science and Technology Press, 1996: 302.
[17] AGULA, et al. Mongolian Medicine(蒙医药学) [M]. Hohhot: Inner Mongolia Education Publishing House, 2010: 46-49.
[18] FAN·NUOERBU. USURILETE translated. UYOU, BAOLONG edited and annotated. The Complete Interpretation of the Fundamental Texts of Mongolian Medicine: Mongolian(蒙医学本续全释:蒙古文)[M]. Chifeng: Inner Mongolia Science and Technology Publishing House, 2015: 3-5.
[19] RASHID-AL-DIN (Persian). The Comprehensive History (史集) [M]. Beijing: The Commercial Press, 1983: 229.
[20] Compiled by the Inner Mongolia Institute of Mongolian Language, Literature and History. The twenty-One Volume Dictionary(二十一卷本辞典)[Z].Hohhot:Inner Mongolia People’s Publishing House, 1977: 354.
[21] Mongolian Encyclopedia Editorial Committee edited. The Mongolian Encyclopedia (Medical Sciences Volume)(蒙古学百科全书医学卷)[M]. Hohhot: Inner Mongolia People’s Publishing House, 2012: 124-361.
[22] LUOBUSANGDANSENGZHALACANG. NAMUJILE translated. BAOLONG edited and annotated. The five works of Mongolian Aoteqi
(Mongolian) (蒙古族奥特奇五著蒙古文) [M]Mongolian) (蒙古族奥特奇五著蒙古文) [M]. Chifeng: Inner Mongolia Science and Technology Publishing House, 2014: 53-54.
[23] TUBDANIMA. ZHA·DAMULIN Compiled. XIJIE edited and annotated. The Coral Beads of Mongolian Medicine(Mongolian) (蒙医珊瑚串珠蒙古文)[M]. Chifeng: Inner Mongolia Science and Technology Publishing House, 2014: 6-68.
[24] HUSIHUI (Yuan Dynasty). The Essentials of Proper Drinking(饮膳正要)[M]. Beijing: China Press of Traditional Chinese Medicine, 2009: 65-72.
[25] YIXIBALAJIER. BUHEBATEER edited and annotated. The White Crystal Mirror(Mongolian)(白晶鉴蒙古文)[M]. Chifeng: Inner Mongolia Science and Technology Publishing House, 2015: 215.
[26] JIGEMUDEDANJINZHAMUSU. AOTEGENBILIGE, DUAN·GUANBUZHABU, RENQING compiled. TONGWAGAJIDE (Mongolian) (通瓦嘎吉德蒙古文) [M]. Hohhot: Inner Mongolia People’s Publishing House, 2015: 50-112.
[27] GUANBUZHABU(Qing Dynasty). WANGQINZHABU, et al, edited, BAI MR annotated. The Essential Medicaments and Their Varieties (Mongolian) (必用药剂诸品蒙古文)[M]. Chifeng: Inner Mongolia Science and Technology Press, 2014: 4-115.
[28] ZHANBALAQUEJIDANSENFORENLAI. The Editorial Committee of Mongolian Medical Classics compiled. The Golden Cabinet of
Mongolian Medicine(Mongolian) (蒙医金匮蒙古文)[M]. Hohhot: Inner Mongolia People’s Publishing House, 2015: 104-189.
[29] AWANGLUOBUSANDANBEIJIANZAN. The Mongolian Medicine Research Institute of Xilingol League translated from Tibetan into Mongolian. Baicuilan edited and annotated . The Universal Remedies Formulas(Mongolian) (普济方剂蒙古文) [M]. Chifeng: Inner Mongolia Science and Technology Publishing House, 2013: 160-187.
[30] LONGRIGEDANDAER (Mongolian).YI·DENGBURILE translated. LUOBUSANG, WANGCHUGE, WURENTUYA transcribed. Hasierdun edited and annotated. Tajod: Annotations on the Four Medical Classics (Mongolian) (塔教得:《四部医典》注释蒙古文)[M]. Chifeng: Inner Mongolia Science and Technology Press, 2013: 304-305.
[31] LUOBUSANGCHULETEMU. LUOBUSANG, NASHENGSANG, WURENTUYA, et al, compiled. The Knowledge of Pharmacy (Mongolian)(识药学蒙古文) [M]. Beijing: Ethnic Publishing House, 1998: 29-30.
[32] LONGRIGEDANDAER. Inner Mongolia Traditional Chinese and Mongolian Medicine Research Institute compiled. Hujilebatu annotated.The Crystal Pearl of Haritaki Unraveling Difficult Classics(Mongolian) (诃黎勒晶珠解疑难经蒙古文上册)[M]. Chifeng: Inner Mongolia Science and Technology Press, 2015: 169-924.
[33] YI XIBALAZHUER.ZHANGBALASHANU, CHAO·GONGBUQUE NUO compiled. The Classics of Mongolian Medicine.ancient books, Gan Lu Si Bu(蒙古医学古籍经典丛书:甘露四部)[M]. Hohhot: Inner Mongolia People’s Press, 1998: 287-291.
[34] Inner Mongolia University Institute of Mongolian Studies Institute of Mongolian Language and Literature. Mongolian-Chinese Dictionary: Chinese Comparison(蒙汉词典:蒙汉对照) [Z]. Hohhot: Inner Mongolia University Press Mongolian-Chinese Comparison(蒙汉词典:蒙汉对照) [Z]. Hohhot: Inner Mongolia University Press, 1999: 390.
[35] GAOSHIGE. DUAN·GUANZHABU, MA YH, NA SHENG compiled. Gao Shi Ge Mei Lin Fang: Mongolian (高世格梅林方:蒙古文)[M]. Hohhot: Inner Mongolia People’s Press, 2015: 89-166.
[36] ZHANBALADAORIJI. GENDENZHALASANG. WANGJILA, SUYALATU collated. WU XJ. NAMJILA annotated. The Canonical Book of Mongolian Medicine: Mongolian (蒙药正典蒙古文)[M]. Chifeng: Inner Mongolia Science and Technology Publishing House, 2015: 40-359.
[37] WANG DH, WANG C, WU SK, et al.Immunomodulation mechanism of "Xieri Wusu"(yellow fluid)-drying Mongolian medicinal menken usu (mercury): a review[J]. Modern Chinese Medicine(中国现代中药), 2022, 24(7): 1219-1224.
[38] TONG HY, HURILEBAGEN, GAOWA, et al.Discussion of the Mongolian Meng Gen Wu Su (mercury) problems in the processing[J]. Lishizhen Medicine and Materia Medica Research(时珍国医国药), 2013, 24(8): 1921-1923.
[39] TONG HY, FAN AR, BAI LF, et al.Comparison of nephrotoxicity induced by Mongolian Meng-Gen-Wu-Su (mercury) processed products, Mongolian Meng-Gen-Wu-Su (Mercury)-18-composition pill and mercuric sulfide, mercuric chloride and mercurous chloride[J]. Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology(世界科学技术中医药现代化), 2015, 17(3): 698-706.
[40] HUO W, LI H, LI L, et al.Study on regulation of CYP450 enzyme system to reduce liver toxicity through compatibility of Aconiti Kusnezoffii Radix Cocta with Chebulae Fructus and Glycyrrhizae Radix et Rhizoma[J]. China Journal of Chinese Materia Medica(中国中药杂志), 2022, 47(6): 1618-1624.
[41] Inner Mongolia Autonomous Region Drug Administration compiled. Standards of Mongolian Medicinal Materials in Inner Mongolia (2021 Edition) (内蒙古蒙药材标准 2021年版)[M]. Chifeng: Inner Mongolia Science and Technology Publishing House, 2022: 56-222.
[42] Inner Mongolia Autonomous Region Drug Administration compiled. Processing Standards for Mongolian Medicine Decoction Pieces (2020 Edition) (内蒙古蒙药饮片炮制规范2020版)[M]. Hohhot: Inner Mongolia People’s Publishing House, 2020: 262-362.
[43] The Pharmacopoeia Committee of the Ministry of Health of the People’s Republic of China compiled. Drug Standards of the Ministry of Health of the People’s Republic of China (Mongolian Medicine Volume)(中华人民共和国卫生部药品标准蒙药分册)[M]. 1998: 198.
[44] BAGENNA. Mongolian Medical Prescriptions: Mongolian(蒙医方剂学:蒙古文)[M]. Hohhot: Inner Mongolia People’s Publishing House, 2007: 45-48.
[45] The Mongolian Medical Editorial Committee compiled. Encyclopedia of Chinese Medicine (Mongolian Medicine)(中国医学百科全书蒙医学)[M]. Shanghai: Shanghai Science and Technology Publishing House, 1992: 178-180.
[46] YANG BC. Chinese Materia Medica (5th Edition of the New Century) (中药学新世纪第五版)[M]. Beijing: China Medical Publishing House, 2021: 411.
[47] SONG LIN.Introduction to Mongolian Pharmacy (蒙药学概论)[M]. Hohhot: Inner Mongolia Education Publishing House, 2012: 158-159.
[48] WU H, LI F. Chinese Herbal Processing (Second Edition) (中药炮制学第2版)[M]. Beijing: People’s Medical Publishing House, 2016: 256-257.
[49] Mongolian Medicine Textbook Review and Compilation Committee Mongolian Herbal Processing Editorial Group compiled. Mongolian Herbal Processing(蒙药炮制学)[M]. Hohhot: Inner Mongolia People’s Publishing House, 1989: 63-64, 230-234.
[50] LUOBUSANG. Mongolian Pharmacy(蒙药学)[M]. Hohhot: Inner Mongolia People’s Publishing House, 2006: 27-32.
[51] B·JIGMED. Overview of the history of mongolian medicine - four stages of development[J]. Chinese Journal of Ethnic Medicine and Pharmacy(中国民族医药杂志), 2007(1): 1-5.