中国药物警戒 ›› 2012, Vol. 9 ›› Issue (8): 487-489.

• 药械质量研究 • 上一篇    下一篇

肺力咳胶囊质量标准的研究

金星, 张清波*   

  1. 黑龙江省食品药品检验检测所,黑龙江 哈尔滨 150001
  • 收稿日期:2012-01-11 出版日期:2012-08-10 发布日期:2015-08-07
  • 通讯作者: 张清波,男,硕士,主任药师,E-mail:qingbo9118@sina.com
  • 作者简介:金星,女,硕士,主管药师,中药质量标准研究。

Study on Quality Standard for Feilike Capsules

JIN Xing, ZHANG Qing-bo   

  1. Heilongjiang Provincial Institute for Food and Drug Control, Heilongjiang Harbin 150001, China
  • Received:2012-01-11 Online:2012-08-10 Published:2015-08-07

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摘要： 目的研究肺力咳胶囊的质量标准。方法重新修订了前胡的薄层鉴别,增加TLC法鉴别红花龙胆、黄芩及RP-HPLC法测定当药苷的含量。含量测定采用Aglient Eclipse XDB C18色谱柱（4.6×250mm,,5μm）;流动相为甲醇-水（20 80）,流速为1.0mL ·min-1,检测波长为247nm。结果鉴别：阴性对照均无干扰;含量：当药苷在0.04076μg~0.24456μg范围内有良好的线性关系（r=0.999）,平均加样回收率为100.03%（n=6）。结论所建方法简单,专属性强,重现性好,可用于肺力咳胶囊的质量控制。

关键词: 前胡, 红花龙胆, 黄芩, 当药苷, 肺力咳胶囊, 高效液相色谱法

Abstract: ObjectiveTo establish a method for the quality standard of Feilike capsules. MethodsRevised the method of TCL identification for Peucedani radix, added the TLC methods for Gentiana rhodantha Franch and Scutellariae radix, and a RP-HPLC method for the determination of Sweroside, with Aglient Eclipse XDB C18 column(4.6×250mm,5μm), methanol-water(20:80) as the mobile phase at the flow rate of 1.0 mL ·min-1.The detection wavelength was 247nm. ResultsNegative controls were non-interference, the linear range was 0.04076μg~0.24456μg(r=0.999) and average recovery(n=6) was 100.03%. ConclusionThe method is convenient, reliable and suitable for quality assessment of Feilike capsules.

Key words: Peucedani radix, Gentiana rhodantha Franch, Scutellariae radix, Sweroside, Feilike capsules, HPLC