中国药物警戒 ›› 2011, Vol. 8 ›› Issue (12): 753-754.

• 药品不良反应监测 • 上一篇    下一篇

748例β-内酰胺类抗菌药物不良反应分析

张树强1, 邢蓉2,*, 王群2, 师佩兰2, 谢冬梅2, 许健2   

  1. 1 蚌埠市药品不良反应监测中心,安徽 蚌埠 233000;
    2 蚌埠医学院第一附属医院药剂科,安徽 蚌埠 233000
  • 收稿日期:2011-05-04 出版日期:2011-12-10 发布日期:2015-07-30
  • 通讯作者: 邢蓉,女,副教授,药事管理与临床药学。E-mail：xingrong9796@163.com
  • 作者简介:张树强,男,主管药师,临床药学与ADR监测。
  • 基金资助:
    本课题系蚌埠市科技局资助科研项目（项目编号：201003022）

Analysis on 748 Cases ofβ-lactam Antibiotics Drug Adverse Reaction

ZHANG Shu-qiang1, XING Rong2, *, WANG Qun2, SHI Pei-lan2, XIE Dong-mei2, XU Jian2   

  1. 1 Adverse Drug Reactions Monitoring Center of Bengbu Region, Anhui Bengbu 233000, China;
    2 First Affiliated Hospital of Bengbu Medical College, Anhui Bengbu 233000, China
  • Received:2011-05-04 Online:2011-12-10 Published:2015-07-30

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摘要： 目的 了解蚌埠地区β-内酰胺类抗菌药物致药品不良反应（ADR）的发生情况。方法 对2010年1~12月蚌埠地区上报的748例β-内酰胺类抗菌药物ADR病例报告,按性别、年龄、给药途径、药品类别、ADR累及系统-器官及临床表现等进行统计、分析。结果 ADR涉及的β-内酰胺类抗菌药物共26种,ADR发生频次以阿莫西林居首位,其次为头孢氨苄和头孢拉啶;主要的ADR类型为皮肤及其附件损害,占47.48%;1例严重ADR。结论 应规范β-内酰胺类抗菌药物的临床应用,以减少ADR的发生率。

关键词: β, -内酰胺类抗菌药物, 药品不良反应, 联合用药

Abstract: Objective To investigate the situation of β-lactam antibiotics drug adverse reactions in Bengbu region. Method According to gender, age, administration route, drug category, organs or systems, clinical manifestations Involved with ADR, and so on, 748 cases of β-lactam antibiotics drug adverse reactions in Bengbu region reported from Jan 2010 to Dec 2010 were analyzed. Results 26 β-lactam antibiotics drugs were involved with ADR. As to the ADR frequence, the highest was related to amoxicillin, and then were related to cephalexin and cephradine. The major organ-system damage involved in ADR was skin and appendages disorders, which accounted for 47.48% of the total, and a serious ADR occurred. Conclusion Clinical appliance of β-lactam antibiotics drug should be standardized to reduce the ADR incidence.

Key words: β-lactam antibiotics drug, adverse drug reaction(ADR), drug combination

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