环孢素注射液血药浓度升高致癫痫发作1例

中国药物警戒 ›› 2019, Vol. 16 ›› Issue (4): 248-251.

环孢素注射液血药浓度升高致癫痫发作1例

张静, 楚明明, 李乐涛, 张蓉^*

陆军军医大学第二附属医院药剂科,重庆 400037

收稿日期:2019-05-09 修回日期:2019-05-09 出版日期:2019-04-20 发布日期:2019-05-09
作者简介:张静,女,本科,主管药师,药品不良反应监测。

One Case of Epileptic Seizure Induced by Increased Blood Concentration of Cyclosporine Injection

ZHANG Jing, CHU Mingming, LI Letao, ZHANG Rong^*

Department of Pharmacy, Second Affiliated Hospital of Army Medical University, Chongqing 400037, China

Received:2019-05-09 Revised:2019-05-09 Online:2019-04-20 Published:2019-05-09

摘要/Abstract

中图分类号:

R994.11

张静, 楚明明, 李乐涛, 张蓉. 环孢素注射液血药浓度升高致癫痫发作1例[J]. 中国药物警戒, 2019, 16(4): 248-251.

ZHANG Jing, CHU Mingming, LI Letao, ZHANG Rong. One Case of Epileptic Seizure Induced by Increased Blood Concentration of Cyclosporine Injection[J]. Chinese Journal of Pharmacovigilance, 2019, 16(4): 248-251.

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参考文献

[1] 曲彩红, 苏向阳. 伏立康唑致环孢素血药浓度升高相关癫痫样发作[J]. 药物不良反应杂志, 2010, 12(5):354-356.
[2] 江灏, 陈英, 何菊英. 1例纯红细胞再生障碍性贫血患者出现癫痫发作的药源性因素分析[J]. 中国药物应用与监测, 2013, 10(3):181-182.
[3] Gaggero R, Haupt R, Fondelli M P, et al.Intractable Epilepsy Secondary to Cyclosporine Toxicity in Children Undergoing Allogeneic Hematopoietic Bone Marrow Transplantation[J]. Journal of Child Neurology, 2006, 21(10):861-866.
[4] Vesole A S, Nagahama Y, Granner M A, et al.Drug-resistant epilepsy development following stem cell transplant and cyclosporine neurotoxicity induced seizures: Case report in an adult and analysis of reported cases in the literature[J]. Epilepsy and Behavior Case Reports, 2018, 10:8-13.
[5] 李瑞莲, 陈文倩, 张丹, 等. 154例肾病综合征患者环孢素A血药浓度监测及其对疗效、安全性的影响分析[J]. 中国药房, 2018, 29(20):2827-2831.
[6] 毕晓莹, 陶沂. 环孢霉素的神经系统毒性[J]. 国际神经病学神经外科学杂志, 2004, 31(6):519-522.
[7] 赖针珍. 环孢素致可逆性后部白质脑病综合征1例[J]. 中国乡村医药, 2018, 25(15):38.
[8] 吴鹏辉, 谢瑶, 赵卫红, 等. 血液病/肿瘤患儿并发可逆性后部白质脑病综合征[J]. 北京大学学报(医学版), 2018, 50(4):662-665.
[9] Valldeoriola F, Graus F, Rimola A, et al.Cyclosporine-associated mutism in liver transplant patients[J]. Neurology, 1996, 46(1):252-254.
[10] 韦恩. 药物相互作用原理与临床应用指南[M]. 人民军医出版社,2011.
[11] 刘振威, 胡卓汉, 蔡映云. 异烟肼和利福平联合用药对健康成人原代肝细胞CYP450同工酶1A2和3A4活性的影响[J]. 中华结核和呼吸杂志, 2005, 28(11):785-788.
[12] Florea N R, Capitano B, Nightingale C H, et al.Beneficial pharmacokinetic interaction between cyclosporine and itraconazole in renal transplant recipients[J]. Transplantation Proceedings, 2003, 35(8):2873-2877.
[13] Gerntholtz T, Pascoe M D, Botha J F, et al.The use of a cyclosporin-ketoconazole combination: Making renal transplantation affordable in developing countries[J]. European Journal of Clinical Pharmacology, 2004, 60(3):143-148.
[14] Iyengar A, Kamath N, Phadke K, et al.Cyclosporine/ketoconazole reduces treatment costs for nephrotic syndrome[J]. Indian Journal of Nephrology, 2013, 23(6):419-423.
[15] 易林高, 吴明钗, 黄鹏, 等. HPLC/MS测定环孢素A单用及联用氟康唑的血药浓度[J]. 中国药物应用与监测, 2016, 13(4):211-213.
[16] Valenzuela R, Torres J P, Salas C, et al.Drug interaction of voriconazole-cyclosporine in children undergoing hematopoietic stem cell transplantation (2013-2014)[J]. Rev Chilena Infectol, 2017, 34(1):14-18.
[17] Masoumi H T, Hadjibabaie M, Vaezi M, et al.Evaluation of the Interaction of Intravenous and Oral Voriconazole with Oral Cyclosporine in Iranian HSCT Patients[J]. Journal of Research in Pharmacy Practice, 2017, 6(2):77-82.
[18] Ishiwata Y, Nagata M, Arai T, et al.Effects of miconazole oral gel on blood concentrations of tacrolimus and cyclosporine: a retrospective observational study[J]. Therapeutic Drug Monitoring, 2016, 38(6):717-721.
[19] Romero A.Effect of voriconazole on the pharmacokinetics of cyclosporine in renal transplant patients[J]. Clinical Pharmacology & Therapeutics, 2002, 71(4):226-234.
[20] 丁春雷, 孙健姿, 张熠, 等. 环孢素浓度异常升高致高尿酸血症1例[J]. 中国药物警戒, 2011, 8(3):190-190.
[21] Yang T, Wu X M, Qiu H Q, et al.Adverse drug interactions as a high-risk factor for lethal post-transplant complications in Chinese population[J]. Clinical Transplantation, 2013, 27(2):255-260.