全面触发工具(GTT)检测住院儿童药品不良事件(ADE)的有效性研究

中国药物警戒 ›› 2017, Vol. 14 ›› Issue (2): 119-122.

• 安全性评价与合理用药 • 上一篇下一篇

全面触发工具(GTT)检测住院儿童药品不良事件(ADE)的有效性研究

吴娟，胡一冰，徐妮

深圳市龙华新区人民医院住院部儿科,广东深圳 518109

收稿日期:2017-03-10 修回日期:2017-03-10 出版日期:2017-02-20 发布日期:2017-03-10
作者简介:吴娟,女,本科,护师,儿科护理。

Effectiveness Study on Global Trigger Tool in Detecting Adverse Drug Events for Children

WU Juan, HU Yi-bing, XU Ni

Department of Pediatrics, People’s Hospital of Longhua New District, Guangdong Shenzhen 518109, China

Received:2017-03-10 Revised:2017-03-10 Online:2017-02-20 Published:2017-03-10

摘要/Abstract

摘要： 目的验证全面触发工具（global trigger tool,GTT）用于检测儿童药品不良事件(adverse drug event,ADE) 的可行性。方法按照抽样间隔数随机抽取本院病案科2014年12月1日至2015年12月1日住院患儿病历600份。采用GTT法进行回顾性分析,对触发器显示阳性的患者进行ADE判定和分析,并将最终确定的ADE进行严重程度分级、累及系统-器官情况分析。结果实际用于审查的病历576份,至少一项触发器阳性者326例,占56.60%（326/576）。26项触发器中,有22项显示阳性,其中以“使用止泻药\微生态药物\口服甲硝唑\万古霉素\去甲万古霉素”占比最高,达24.85%（81例次）。GTT法确定ADE为107例次,检出率为18.58%（107/576）。ADE伤害分级集中在E级（短暂性伤害）与F级（中度伤害）,累及系统-器官以胃肠系统例次最高,占50.00%（71/142）。结论 GTT在防范儿童ADE方面具有积极作用,但尚待完善。

关键词: 药品不良事件, 全面触发工具, 触发器, 儿童患者

Abstract: Objective To evaluate the effectiveness and popularization value of global trigger tool(GTT) in detecting adverse drug event(ADE) for children.Methods Six hundred cases medical records of inpatient were randomly selected from December 2014 to December 2015, then were retrospectively reviewed according to GTT method. The positive triggers- related situations were further reviewed to identify or exclude ADE. All ADEs were evaluated for severity classification and involved system-organs.Results There were 576 medical records, and 326 patients (56.60%, 326/576) with at least one trigger positive. Twenty-two out of the 26 triggers were positive. Among them, the proportion of “antidiarrheal / microecological drugs/oral metronidazole/vancomycin/norvancomycin” was the highest (24.85%) . 107 ADE cases were determined by GTT method, and the detection rate was 18.58% (107/576). The damage classifications of ADE were concentrated as “mild harm” and “moderate harm”. The number of organs involved was the highest (50.00%) in the gastrointestinal system.Conclusion GTT plays a positive role in preventing adverse drug events, while it still needs to be optimized.

Key words: adverse drug event, global trigger tool, trigger, pediatric patients

中图分类号:

R969.3

吴娟，胡一冰，徐妮. 全面触发工具(GTT)检测住院儿童药品不良事件(ADE)的有效性研究[J]. 中国药物警戒, 2017, 14(2): 119-122.

WU Juan, HU Yi-bing, XU Ni. Effectiveness Study on Global Trigger Tool in Detecting Adverse Drug Events for Children[J]. Chinese Journal of Pharmacovigilance, 2017, 14(2): 119-122.

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全面触发工具(GTT)检测住院儿童药品不良事件(ADE)的有效性研究

Effectiveness Study on Global Trigger Tool in Detecting Adverse Drug Events for Children

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