中国药物警戒 ›› 2016, Vol. 13 ›› Issue (5): 298-302.

• 安全性评估与合理用药 • 上一篇    下一篇

注射用硝普钠与氯化钠注射液配伍后使用时间延长至26 小时的临床研究

林小明1,黄敏2,谢培德3   

  1. 1广西贵港市人民医院，广西 贵港 537100;
    2广西中医药大学附属瑞康医院，广西 南宁530011;
    3广西食品药品检验所，广西 南宁530001
  • 收稿日期:2015-12-25 修回日期:2016-06-30 出版日期:2016-05-20 发布日期:2016-06-30
  • 作者简介: 林小明，男，本科，副主任药师，临床药学。E-mail：lxmgg168@126.com

Clinical Study on Compatibility of Sodium Nitroprusside for Injection and Sodium Chloride Injection after Prolonged Use to 26 h

LIN Xiao-ming1, HUANG Min2, XIE Pei-de3   

  1. 1People’s Hospital of Guigang City, Guangxi Guigang 537100, China;
    2Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, Guangxi Nanning 530011, China;
    3Guangxi Institute for Food and Drug Control, Guangxi Nanning 530021, China
  • Received:2015-12-25 Revised:2016-06-30 Online:2016-05-20 Published:2016-06-30

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摘要： 目的 为注射用硝普钠与氯化钠注射液临床合理配伍提供参考。方法 选择3组高血压危象患者，分别静脉滴注配制4 h内（A组，n=28）、12~14 h内（B组，n=29）、24~26 h内（C组，n=33）注射用硝普钠与氯化钠注射液配伍液，检测各组患者血液中氰酸盐含量，并同时进行血气分析，记录硝普钠的用量；对配伍后26 h 硝普钠配伍液的降解度和氰化物含量进行检测。结果 按常规配制，使用注射用硝普钠与氯化钠注射液配伍液26 h内是安全有效的。结论 临床上延长注射用硝普钠与氯化钠注射液配伍液使用时间至26 h是可行的。

关键词: 硝普钠, 稳定性, 氰化物, 血气分析

Abstract: Objective To provide scientific basis for clinical rational compatibility of sodium nitroprusside (SNP) for injection and sodium chloride (NS) injection. Methods The compatible solution of SNP and NS injection was given intravenously in three ways for the patients in 3 different groups of hypertensive crisis. The solution was given within 4 h, 12 to 14 h, and 24 to 26 h after preparation for each group of patients respectively. The blood contents of cyanide (CN) were measured, and blood gas analyses were performed at the same time, and the amounts of the SNP used were recorded. The contents of CN and the degradation of sodium nitroprusside in the compatible solution of SNP and NS injection were also measured 26 h after its preparation. Results As conventional preparation, the compatible solution of SNP and NS injection used within 26 h is safe and effective. Conclusion It is scientific to use the compatible solution of SNP and NS injection until 26 h after its preparation in clinic.

Key words: sodium nitroprusside, stability, cyanide, blood gas analysis

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