中国药物警戒 ›› 2013, Vol. 10 ›› Issue (4): 247-248.

• 医院药事管理与合理用药 • 上一篇    下一篇

头孢噻肟钠与奥硝唑氯化钠注射液配伍变色的考察

李荣1,任美萍2,曾敬怀1*,张润3,蒋英蓝1   

  1. 1.泸州市人民医院药剂科,四川泸州646000；
    2.泸州医学院药物与功能性食品研究中心,四川泸州646000；
    3.泸州市人民医院护理部,四川泸州46000
  • 收稿日期:2012-10-29 修回日期:2016-03-09 出版日期:2013-04-08 发布日期:2016-03-09
  • 通讯作者: 曾敬怀,女,副主任药师,医院药学。 E-mail:58021067@qq.com
  • 作者简介:李荣,男,硕士,临床药师,临床药学。

Discoloration of Compatibility between Cefotaxime Sodium and Ornidazole Sodium Chloride Injection

LI Rong1, REN Mei-ping2 ,ZENG Jing-Huai1* ,ZHANG Run3 ,JIANG Ying-lan1   

  1. 1.Department of Pharmacy, People's Hospital of Luzhou City, Sichuan Luzhou 646000,China;
    2.Medicine and Functional Food Research Center of Luzhou Medical College, Sichuan Luzhou 646000,China;
    3.Department of Nursing, People's Hospital of Luzhou City, Sichuan Luzhou 646000, China
  • Received:2012-10-29 Revised:2016-03-09 Online:2013-04-08 Published:2016-03-09

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摘要： 目的 考察注射用头孢噻肟钠与奥硝唑氯化钠注射液配伍后的稳定性。方法 测定两药配伍后的pH 值,溶液颜色变化,采用紫外分光光度计测定吸收曲线变化及含量变化。结果 头孢噻肟钠在236nm,奥硝唑在319nm 处有最大吸收；混合液在40min 时,由微淡黄色澄清液变为淡粉红色；在4h 内,混合液的外观、pH 值、峰形、含量均无明显变化。结论 头孢噻肟钠与奥硝唑氯化钠注射液配伍后可能会变色,临床应避免配伍。

关键词: 头孢噻肟钠, 奥硝唑, 紫外分光光度法, 稳定性

Abstract: Objective To investigate the compatible stability of cefotaxime sodium and ornidazole chloride sodium injection. Methods The contents and absorption curves of cefotaxime sodium and ornidazole sodium chloride injection after mix were determined by ultraviolet spectrophotometry. The appearance of the solution was observed and pH value was determined. Results The absorption peaks of cefotaxime sodium and ornidazole sodium chloride injection were at 236 nm and 319 nm, respectively. The mixture changed from light yellow clear liquid to pale pink at 40min.There were no evident changes in appearance, pH, content and absorption curves during4 hours. Conclusion The solution might change in color after cefotaxime sodium and ornidazole sodium chloride injection were mixed. Such compatibility should be avoided in the clinic.

Key words: cefotaxime sodium, ornidazole, ultraviolet spectrohotometry, stability

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