中国药物警戒 ›› 2013, Vol. 10 ›› Issue (5): 309-311.

• 药械安全性研究 • 上一篇    下一篇

155例喹诺酮类药品不良反应分析

钟晗,刘晓琰*,崔敏,苏颖杰   

  1. 上海交通大学医学:附属仁济医:药剂科,上海 200127
  • 收稿日期:2012-12-07 修回日期:2016-03-09 出版日期:2013-05-08 发布日期:2016-03-09
  • 通讯作者: 刘晓琰,女,硕士,副主任药师。E-mail:xiaoyan630@gmail.com
  • 作者简介:钟晗,女,硕士,药剂师。

Analysis of 155 reports of ADR Induced by Quinolones

ZHONG Han ,LIU Xiao-yan* ,CUI Min ,SU Ying-jie   

  1. Department of Pharmacy, Renji Hospital Affliated to the School of Medicine of Shanghai Jiao Tong University, Shanghai 200127, China
  • Received:2012-12-07 Revised:2016-03-09 Online:2013-05-08 Published:2016-03-09

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摘要： 目的 研究喹诺酮类药物在临床治疗中发生的不良反应（ADR）情况,寻找应对该类药物ADR的临床策略。方法 采用回顾性研究方法,对我院2004~2011 年上报的喹诺酮类药物ADR 进行系统分析。结果 155 例ADR 报表中涉及9 种喹诺酮类药物,左氧氟沙星ADR 例次最多（105 例次）。主要不良反应表现为过敏反应（40.4%）和消化系统症状（27.1%）。结论 对喹诺酮类药物的临床应用需加强监测,促进合理用药。

关键词: 喹诺酮类药物, 药品不良反应, 临床策略

Abstract: Abstract : Objective To determine adverse drug reaction (ADR ) occurrence associated with quinolones in clinical practices. Methods 155 reports of quinolones-induced ADR from 2010 to 2011 were analyzed. Results Nine drugs of quinolones were involved in 155 ADR reports, among which levofloxacin resulted in ADR most frequently(105 cases). The ADRs manifestations mainly covered allergies(40.4%) and digestive system disease symptoms(27.1%).Conclusion It is necessary to monitor clinical application of quinolones, therefore promote rational use of drug.

Key words: quinolones, adverse drug reaction(ADR), clinical strategies

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