中药肝毒性及肝脏保护作用的研究方法进展

中国药物警戒 ›› 2013, Vol. 10 ›› Issue (7): 408-410.

中药肝毒性及肝脏保护作用的研究方法进展

顾立强,马冰洁,孟夏,毕开顺,陈晓辉

沈阳药科大学药学院,辽宁沈阳 110016

收稿日期:2012-12-13 修回日期:2016-03-09 出版日期:2013-07-08 发布日期:2016-03-09
通讯作者: 陈晓辉,女,博士生导师,中药质量控制方法的研究。 E-mail：cxh_syphu@yahoo.com.cn
作者简介:顾立强,男,硕士,中药质量控制方法研究。

Advances of Research Methods for the Herbal Hepatotoxic and Hepatoprotective Properties

GU Li –qiang, MA Bing –jie, MENG Xia, BI Kai –shun, CHEN Xiao -hui

School of Pharmacy, Shenyang Pharmaceutical University, Liaoning Shenyang 110016, China

Received:2012-12-13 Revised:2016-03-09 Online:2013-07-08 Published:2016-03-09

摘要/Abstract

摘要： 近年来,中药的肝毒性越来越被人们所了解和重视,中药的肝毒性及肝脏保护作用的研究方法已被广泛建立。与传统的动物体内药代动力学实验相比,精密肝切片法、肝细胞及亚细胞模型体外实验法得以直观地反映出药物对细胞及组织的影响。基因组学,蛋白质组学,代谢组学的方法利用质谱联用技术找出新的生物标记物,阐明肝毒性机制。这一系列的进展为广大的药学工作者对中药肝毒性及肝脏保护作用的研究提供了较大的帮助。

关键词: 中药肝毒性, 精密肝切片, 代谢组学, 生物标记物

Abstract: Herbal hepatotoxicity is increasingly being understood and valued by people in recent years.The research Methods for the herbal hepatotoxic and hepatoprotective properties have been widely developed.Compared with the conventional in vivo experiment of pharmacokinetics,the effect to the cells and tissues can be derectly reflected by the Precision-Cut Liver Slices and the hepatocytes and the subcellular models.It is very meaningful that the in vivo metabolic mechanism was illustrated and the new biomarkers were found through the Methods of genomics, proteomics and metabonomics combined with mass spectrometry technology. The series of advances will help the study of the herbal hepatotoxic and hepatoprotective properties.

Key words: herbal hepatotoxicity, Precision-Cut Liver Slices, metabolism, biomarker

中图分类号:

R285.1

顾立强,马冰洁,孟夏,毕开顺,陈晓辉 . 中药肝毒性及肝脏保护作用的研究方法进展[J]. 中国药物警戒, 2013, 10(7): 408-410.

GU Li –qiang, MA Bing –jie, MENG Xia, BI Kai –shun, CHEN Xiao -hui. Advances of Research Methods for the Herbal Hepatotoxic and Hepatoprotective Properties [J]. Chinese Journal of Pharmacovigilance, 2013, 10(7): 408-410.

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