中国药物警戒 ›› 2013, Vol. 10 ›› Issue (9): 520-522.

• 基础与临床研究 • 上一篇    下一篇

248例脑肿瘤患者围手术期应用丙戊酸钠血药浓度监测分析

李铮燃12,朱乐亭1,高晨1,黄佳1,李激扬3*,崔向丽1*   

  1. 1. 首都医科大学附属北京天坛医院药剂科,北京100050；
    2.北京市通州区张家湾卫生院药剂科,北京101113；
    3.中国中医科学院西苑医院药剂科,北京100091
  • 收稿日期:2013-09-03 修回日期:2016-03-09 出版日期:2013-09-08 发布日期:2016-03-09
  • 通讯作者: 李激扬,女,本科,主管药师,临床药学。 E-mail:ricky_ yang@sina.com
  • 作者简介:李铮燃,女,本科,药师,医院药学。

Analysis of Blood Concentrations of Sodium Valproate in 248 Cases of Perioperative Patients with Brain Tumors

LI Zheng-ran1 ,ZHU Yue-ting1 ,GAO Chen1, HUANG Jia1, LI Ji-yang3* ,CUI Xiang-li1*   

  1. 1.Pharmacy Department, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China;
    2.Pharmacy Department, Tongzhou Zhangjiawan Hospital, Beijing 101113, China;
    3.Pharmacy Department, Xiyuan Hospital, China Science Academy of Traditional Chinese Medicine, Beijing 100091, China
  • Received:2013-09-03 Revised:2016-03-09 Online:2013-09-08 Published:2016-03-09

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摘要： 目的 分析血药浓度监测对丙戊酸钠预防神经外科术后癫痫发作的意义,为临床提供参考。方法 回顾性分析2012 年我院神经外科248例脑肿瘤患者围手术期应用丙戊酸钠的血药浓度结果,并根据术后患者的临床资料,癫痫发作情况,评估丙戊酸钠围手术期预防癫痫的疗效。结果 血药浓度在正常治疗范围内有160例,占64.5%,高于正常治疗浓度范围有18例,占7.3%,低于正常治疗浓度范围70 例,占28.2%。结论丙戊酸钠的血药浓度易受多种因素的影响,应根据患者的基本情况,通过血药浓度监测进行个体化给药,使丙戊酸钠维持有效治疗浓度对围手术期预防癫痫有重要意义。

关键词: 丙戊酸钠, 围手术期, 预防, 血药浓度, 个体化治疗

Abstract: Objective To discuss the role of blood concentration monitoring of sodidum valproate in preventing postoperative seizure. Methods 248 cases of sodium valproate blood concentration of brain tumor patients were retrospective analyzed in 2012, and the prophylaxis effect of epilepsy was assessed through the analysis of postoperative epilepspy in hospital. Results Normal treatment concentration was found in 160 cases(64.5%), 18 cases(7.3%) were higher than normal treatment concentration, and 70 cases(28.2% ) below the normal treatment concentration. Conclusion The blood concentration of sodium valproate was influenced by many factors. According to patients' basic situation and blood concentration monitoring, the individualized medication should be made so as to Keep an effective therapeutic concentration of sodium valproate to prevent seizares during the perioperative period.

Key words: sodium valproate, perioperative period, prophylaxis, blood concentration, individualized medication

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