中国药物警戒 ›› 2016, Vol. 13 ›› Issue (1): 5-8.

• 基础与临床研究 • 上一篇    下一篇

西归对小鼠学习记忆功能的影响

董寿堂1,王成军2,张旭强1,朱桂荣2,杜一民2   

  1. 1.保山中医药高等专科学校 ,云南 保山 67800 ;
    2.大理学院药学院 ,云南 大理 671000
  • 收稿日期:2015-01-26 修回日期:2016-02-25 出版日期:2016-01-08 发布日期:2016-02-25
  • 作者简介:董寿堂, 男, 硕士, 讲师, 中草药现代药理学的研究。

Effects of Xigui on Learning and Memory Function in Mice

DONG Shou-tang1, WANG Cheng-jun2, ZHANG Xu-qiang1, ZHU Gui-rong2, DU Yi-ming2   

  1. 1.Baoshan College of Traditional Chinese Medicine, Yunnan Baoshan 67800, China;
    2.Faculty of Pharmacy, Dali University, Yunnan Dali 671000, China
  • Received:2015-01-26 Revised:2016-02-25 Online:2016-01-08 Published:2016-02-25

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摘要： 目的 研究西归对小鼠学习记忆功能的影响。方法 采用跳台法、避暗法观察西归对东莨菪碱、亚硝酸钠、乙醇所致小鼠学习记忆功能障碍的影响。结果 与模型组及溶剂组比较 ,西归能明显延长东莨菪碱、亚硝酸钠、乙醇所致学习记忆障碍小鼠的潜伏期（ P<0.05或 P<0.01） ,并能降低错误次数（ P<0.05或 P<0.01）。结论 西归具有改善小鼠学习记忆障碍作用。

关键词: 西归, 小鼠, 学习记忆

Abstract: Objective To study the function of learning and memory of Xigui in mice. Methods The Methods of step-down test and step-through test were used to research the effects of Xigui on impairment of learning and memory in mice induced by scopomamine, sodium nitrite and ethanol. Results Compared with the model and solvent group, Xigui could significantly prolong the time of latency and decrease the number of errors on impairment of learning and memory in mice (P<0.05 orP<0.01). Conclusion Xigui could improve the learning and memory disorder of mice.

Key words: Xigui, mice, learning and memory

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