中国药物警戒 ›› 2010, Vol. 7 ›› Issue (6): 321-323.

• 基础研究 •    下一篇

娑罗子提取物对阿司匹林致胃溃疡作用的研究

辛文妤, 张雷明, 王天, 傅风华*   

  1. 山东省烟台大学药学院,山东 烟台 264005
  • 收稿日期:2016-02-22 修回日期:2016-02-22 出版日期:2010-06-08 发布日期:2016-02-22
  • 通讯作者: 傅风华,男,博士,药理学。E-mail: fufenghua@sohu.com
  • 作者简介:辛文妤,女,在读硕士研究生,药理学。

The Protective Effect of Semen Aesculi Extracts on Gastric Ulcer Induced by Aspirin

XIN Wen-yu, ZHANG Lei-ming, WANG Tian, FU Feng-hua*   

  1. School of Pharmacology, Yantai University, Shandong Yantai, 264005, China
  • Received:2016-02-22 Revised:2016-02-22 Online:2010-06-08 Published:2016-02-22

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摘要： 目的 研究娑罗子提取物（SAE）对阿司匹林所致胃溃疡的保护作用,为阿司匹林安全用药提供依据。方法 用阿司匹林制备溃疡模型,小鼠连续5天灌胃给予SAE（3.5、7、14 mg/kg）或在制备溃疡模型前、后不同时间点灌胃给予SAE（7 mg/kg）,于显微镜下观察胃溃疡指数。结果 与模型组比较,SAE（7、14 mg/kg）显著降低溃疡指数（P < 0.05）。制备溃疡模型同时给予SAE（7 mg/kg）可以明显降低溃疡指数。结论 娑罗子提取物对阿司匹林所致胃溃疡有预防作用。

关键词: 阿司匹林, 胃溃疡, 娑罗子提取物

Abstract: Objective To study the protective effect of Semen Aesculi extracts(SAE) on gastric ulcer induced by aspirin in mice. Methods The gastric ulcer was induced by aspirin. SAE(3.5, 7, 14 mg/kg) were administered orally once daily for five consecutive days, or the SAE(7mg/kg) was administered orally before or after the administration of aspirin. The gastric mucosa was examined under a dissecting microscope. Results The level of gastric mucosal lesions was lower in mice treated by SAE(7 or 14 mg/kg)(P<0.05). Simultaneous SAE(7mg/kg) administration with aspirin treatment attenuated the level of gastric mucosal lesions. Conclusion Semen Aesculi extracts can protect the mice from gastric ulcer induced by aspirin.

Key words: aspirin, gastric ulcer, Semen Aesculi extracts

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