中国药物警戒 ›› 2010, Vol. 7 ›› Issue (2): 70-72.

• 基础研究 • 上一篇    下一篇

北豆根不同组分对小鼠急性毒性的影响

杨倩1,2, 罗栋1,2, 赵燕3, 孙蓉1*   

  1. 1山东省中医药研究院,山东 济南 250014;
    2山东中医药大学,山东 济南 250355;
    3国家食品药品监督管理局药品评价中心,北京 100045
  • 收稿日期:2016-02-19 修回日期:2016-02-19 出版日期:2010-02-08 发布日期:2016-02-19
  • 通讯作者: 孙蓉,女,研究员,中药药理与毒理研究。
  • 作者简介:杨倩,女,研究生,中药药理与毒理研究。

Influence of Different Components on Acute Toxicity of Rhizoma Menispermi in mice

YANG Qian1,2, LUO Dong1,2, ZHAO Yan3, SUN Rong1,*   

  1. 1Shandong Academy of Chinese Medicine, Shandong Jinan 250014, China;
    2Shandong University of Traditional Chinese Medicine, Shandong Jinan 250355, China;
    3Center for Drug Reevaluation, SFDA, Beijing 100045, China
  • Received:2016-02-19 Revised:2016-02-19 Online:2010-02-08 Published:2016-02-19

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摘要： 目的 对北豆根全组分、水提组分、醇提组分进行小鼠急性毒性考察。方法 采用经典的急性毒性实验方法分别测定北豆根全组分、水提组分、醇提组分的小鼠口服最大给药量、最大耐受量、半数致死量。结果 北豆根全组分的最大给药量为15.96g·kg-1,水提组分的最大耐受量为92.12g·kg-1,醇提组分的半数致死量为75.116g·kg-1。结论 北豆根醇提组分急性毒性大于水提组分,全组分基本无毒。

关键词: 北豆根, 全组分, 水提组分, 醇提组分, 急性毒性

Abstract: To study the acute toxicity of different components of Rhizoma Menispermi, the acute toxic study on all-components,water extract and alcohol extract of Rhizoma Menispermi to mice were developed in this paper. Ig all-components,water extract and alcohol extract of Rhizoma Menispermi to mice and the MLD, MTD, LD50 were tested differently by the classic Methods of acute toxicity. The Results showed that the MLD of all-components is 15.96g·kg-1;the MTD of water extract is 92.12g·kg-1 and the LD50 of alcohol extract is75.116 g·kg-1. We can draw a Conclusion from the Results that the size order of acute toxicity of different components in Rhizoma Menispermi is alcohol extra ct>water extract. The all-components is atoxic on the whole. It can provide experimental basis for clinical safe medication.

Key words: Rhizoma Menispermi, all-components, water extract, alcohol extract, acute toxicity

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