中国药物警戒 ›› 2025, Vol. 22 ›› Issue (7): 771-775.
DOI: 10.19803/j.1672-8629.20240969

• 基础与临床研究 • 上一篇    下一篇

二巯丙磺钠注射液在肝豆状核变性患者驱铜治疗中的过敏反应及治疗

余勇1, 马守亮2,*, 盛玉琴3   

  1. 1安徽中医药大学第一临床医学院,安徽 合肥 230038;
    2安徽中医药大学第一附属医院老年病中心脑病科,安徽 合肥 230031;
    3上海中医药大学附属曙光医院安徽医院护理部,安徽 合肥 230031
  • 收稿日期:2024-12-11 出版日期:2025-07-15 发布日期:2025-07-17
  • 通讯作者: *马守亮,男,硕士,主任医师·硕导,中西医结合防治肝豆状核变性研究。E-mail: mashouliang1@163.com。
  • 作者简介:余勇,男,在读硕士,中西医结合防治肝豆状核变性。
  • 基金资助:
    安徽省重点研究与开发计划项目（2022e07020082）; 国家中医药管理局第七批全国老中医专家学术经验继承资助项目（国中医药人教函〔2022〕76号）; 安徽省第一届骨干人才培养项目（皖卫函〔2022〕392号）; 2024年度安徽省高等学校科学研究项目（2024AH052736、2024AH052731）

Allergic Reactions and Treatment Involving Sodium Dimercaptopropane Sulfate Injection during Copper Chelation for Wilson’s Disease

YU Yong1, MA Shouliang2,*, SHENG Yuqin3   

  1. 1The First Clinical Medical College of Anhui University of Chinese Medicine, Hefei Anhui 230038, China;
    2Department of Brain Disease, Geriatric Center, the First Affiliated Hospital of Anhui University of Traditional Chinese Medicine, Hefei Anhui 230031, China;
    3Department of Nursing, Anhui Hospital, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Hefei Anhui 230031, China
  • Received:2024-12-11 Online:2025-07-15 Published:2025-07-17

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摘要： 目的 探讨肝豆状核变性（WD）患者使用二巯丙磺钠（DMPS）驱铜治疗过程中发生过敏反应的临床特点及处理方法。方法 回顾性分析2023年1月1日至2024年6月30日于安徽中医药大学第一附属医院脑病中心接受DMPS治疗的WD患者。通过电子病历筛选发生过敏反应的患者,记录其基本信息、药物过敏史及过敏反应的类型、临床表现、处理措施等,并对过敏反应进行分级。结果 共纳入1 810例患者,过敏反应发生率为24.09%（436例）,其中1级占46.56%,2级占52.29%,3级占1.15%。临床表现以皮疹、皮肤瘙痒和发热多见。大多数患者经抗过敏治疗后,过敏症状在2~4 d缓解。结论 DMPS驱铜治疗中过敏反应发生率较高,临床应密切监测并及时处理,以提高治疗安全性和有效性。

关键词: 二巯丙磺钠, 驱铜治疗, 肝豆状核变性, 过敏反应, 抗过敏治疗, 脱敏治疗, 回顾性研究

Abstract: Objective To explore the clinical characteristics and management Methods of allergic reactions that occur during copper chelation with sodium dimercaptopropane sulfonate (DMPS) in patients with Wilson’s disease (WD). Methods The clinical data of WD patients who received DMPS treatment at the Brain Disease Center of the First Affiliated Hospital of Anhui University of Chinese Medicine between January 1, 2023 and June 30, 2024 was retrospectively analyzed. Patients with allergic reactions were identified from electronic medical records. Information on demography, drug allergy history, types and clinical manifestations of allergic reactions, and management strategies were collected. Allergic reactions were graded according to the Immediate Drug Reaction Grading Scale of the United States Drug Allergy Registry (USDAR). Results A total of 1 810 patients were included. The incidence of allergic reactions was 24.09% (436 cases), among which grade 1 accounted for 46.56%, grade 2 52.29%, and grade 3 1.15%. The clinical manifestations were primarily rash, skin itching and fever. The allergic symptoms of most of the patients were relieved 2 to 4 days after anti-allergic treatment. Conclusion The incidence of allergic reactions is relatively high in patients during copper chelation with DMPS. To improve the safety and effectiveness of this treatment regimen, it is critical to monitor the occurrence of allergic reactions in clinical practice and manage them without delay.

Key words: Sodium Dimercaptopropane Sulfate, Copper Chelation Therapy, Wilson's Disease, Allergic Reaction, Antiallergic Treatment, Desensitization Therapy, Retrospective Study

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